Journal Article Ppublish 2 citations
PubMed: 40250166 DOI: 10.1016/j.jnha.2025.100557
Association of life's essential 8 with leukocyte telomere length and mitochondrial DNA copy number: Findings from the population-based UK Biobank study.
J Nutr Health Aging 29(7):100557
Authors: Yu Tian, Shuang Kong, Li Mao, Guoying Wang, Jinxing He, Fang Lei, Lijin Lin, Jian Li
Affiliations
- Department of Neurology, Huanggang Central Hospital of Yangtze University, Huanggang, China; State Key Laboratory of New Drug Discovery and Development for Major Diseases, Gannan Medical University, Ganzhou, China; Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou, China.
- Department of Neurology, Huanggang Central Hospital of Yangtze University, Huanggang, China.
- State Key Laboratory of New Drug Discovery and Development for Major Diseases, Gannan Medical University, Ganzhou, China; Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou, China.
- Medical Science Research Centre, Zhongnan Hospital of Wuhan University, Wuhan, China.
- State Key Laboratory of New Drug Discovery and Development for Major Diseases, Gannan Medical University, Ganzhou, China; Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
- Department of Oncology, Huanggang Central Hospital of Yangtze University, Huanggang, China.
Abstract
OBJECTIVES
To explore the association of Life's Essential 8 (LE8) levels with leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN).
DESIGN
A cross-sectional study.
SETTING AND PARTICIPANTS
225,692 participants aged 37-73 year from the UK Biobank cohort enrolled from 2006 to 2010.
MEASUREMENTS
The LE8 score (0-100) was divided into low (<50), moderate (50-79), and high cardiovascular health (CVH) (≥80) categories, based on health behaviors and factors defined by the American Heart Association. LTL was measured by a validated quantitative polymerase chain reaction method. mtDNA-CN was reacted by standardized SNP probe intensities. The association of CVH (as both a continuous and categorical variable) with LTL and mtDNA-CN was examined using multiple linear regression.
RESULTS
Of 225,692 participants, 5.3% had low CVH, 81.2% had moderate CVH, and 13.4% had high CVH. Participants with higher CVH were usually younger, female, better educated, of higher socioeconomic status, and with a lower prevalence of comorbidities. After adjusting for confounders, a higher LE8 score is associated with longer LTL (Beta = 0.075, P < 0.05) and increased mtDNA-CN (Beta = 0.094, P < 0.05). We also observed that this association was evident in the health behavior score (diet, physical activity, nicotine exposure, and sleep) and the health factors score (BMI, non-HDL cholesterol, blood glucose, and blood pressure), with a stronger positive association of health factors with LTL and mtDNA-CN (Beta = 0.019, P < 0.05; Beta = 0.037, P < 0.05).
CONCLUSIONS
Higher CVH is associated with longer LTL and increased mtDNA-CN.
MeSH
Blood, Health Behavior, Aging, Dna, Mitochondrial, Leukocytes, Nutritional Physiological Phenomena, Dna, Telomere