Journal Article Review Epublish 1 citation
PubMed: 40255918 DOI: 10.1002/mco2.70168
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy.
MedComm (2020) 6(5):e70168
Authors: Yao Shen, Nairui Fan, Shu-Xia Ma, Xin Cheng, Xuesong Yang, Guang Wang
Affiliations
- International Joint Laboratory for Embryonic Development & Prenatal Medicine Division of Histology and Embryology School of Medicine Jinan University Guangzhou China. Key Laboratory for Regenerative Medicine of the Ministry of Education Jinan University Guangzhou China.
- Basic Medical College of Jiamusi University Heilongjiang China.
- International Joint Laboratory for Embryonic Development & Prenatal Medicine Division of Histology and Embryology School of Medicine Jinan University Guangzhou China.
- Key Laboratory for Regenerative Medicine of the Ministry of Education Jinan University Guangzhou China.
- International School Guangzhou Huali College, Zengcheng Guangzhou China.
- Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory Guangdong Second Provincial General Hospital School of Medicine Jinan University Guangzhou China.
Abstract
Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and metabolic abnormalities. These mechanisms involve dysfunctions in the gut-brain axis, gut-liver axis, and others to cause broader effects. Although the association between diseases caused by dysbiosis has been extensively studied, many questions remain regarding the specific pathogenic mechanisms and treatment strategies. This review begins by examining the causes of gut microbiota dysbiosis and summarizes the potential mechanisms of representative diseases caused by microbiota imbalance. It integrates clinical evidence to explore preventive and therapeutic strategies targeting gut microbiota dysregulation, emphasizing the importance of understanding gut microbiota dysbiosis. Finally, we summarized the development of artificial intelligence (AI) in the gut microbiota research and suggested that it will play a critical role in future studies on gut dysbiosis. The research combining multiomics technologies and AI will further uncover the complex mechanisms of gut microbiota dysbiosis. It will drive the development of personalized treatment strategies.
MeSH
Dysbiosis, Precision Medicine, Research, Therapeutics, Artificial Intelligence, Gastrointestinal Microbiome, Microbiota
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