Journal Article Epublish 6 citations
PubMed: 40278432 DOI: 10.3390/neurolint17040061
Estrogen-Mediated Neural Mechanisms of Sex Differences in Burning Mouth Syndrome.
Neurol Int 17(4)
Authors: Takahiko Nagamine
Affiliations
- Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Yamaguchi 747-0066, Japan.
- Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan.
Abstract
BACKGROUND/OBJECTIVES
Burning mouth syndrome (BMS) is a chronic pain disorder of the oral cavity in the absence of organic disease and is prevalent among menopausal women. Estrogen may be involved in the formation of nerves involved in pain.
METHODS
This paper presents an inferred mechanism for the relationship between estrogen and BMS based on a synthesis and interpretation of findings from a selection of published studies.
RESULTS
Estrogen influences the formation of neural circuits in BMS by dividing the complex pain circuit into the following three components: the peripheral pain circuit, brain network pain circuit, and memorized pain circuit.
CONCLUSIONS
The development of BMS may be influenced by the formation of neural circuits by sex hormones.
MeSH
Estrogens, Pain, Sex Characteristics, Default Mode Network, Sex, Mouth, Burning Mouth Syndrome, Sex Differences
Cited by
- Role of Brain Networks in Burning Mouth Syndrome: A Narrative Review. Dent J (Basel), 2025
- Potential Target Receptors for the Pharmacotherapy of Burning Mouth Syndrome. Pharmaceuticals (Basel), 2025