Journal Article Review Ppublish
PubMed: 40280866 DOI: 10.1021/acsbiomaterials.5c00473
Platelet Extracellular Vesicles as Natural Delivery Vehicles for Mitochondrial Dysfunction Therapy?
ACS Biomater Sci Eng 11(5):2601-2621
Authors: Hsien Chang Yeh, Kirti Gupta, Ya-Hsuan Lu, Abinaya Srinivasan, Liling Delila, Nguyen Tran Hai Yen, Ariunjargal Nyam-Erdene, Thierry Burnouf
Affiliations
- School of Medicine, College of Medicine, Taipei Medical University, Xin-Yi Campus, Taipei City 110, Taiwan.
- International Graduate Program in Medicine, College of Medicine, Taipei Medical University, Xin-Yi Campus, Taipei 110, Taiwan.
- School of Biomedical Engineering, Taipei Medical University, Shuang-Ho Campus, New Taipei City 110, Taiwan.
- International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Shuang-Ho Campus, New Taipei City 110, Taiwan.
- Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Shuang-Ho Campus, New Taipei City 110, Taiwan.
- International PhD Program in Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Abstract
Mitochondria are vital for energy production, metabolic regulation, and cellular signaling. Their dysfunction is strongly implicated in neurological, cardiovascular, and muscular degenerative diseases, where energy deficits and oxidative stress accelerate disease progression. Platelet extracellular vesicles (PEVs), once called "platelet dust", have emerged as promising agents for mitigating mitochondrial dysfunction. Like other extracellular vesicles (EVs), PEVs carry diverse molecular cargo and surface markers implicated in disease processes and therapeutic efficacy. Notably, they may possibly contain intact or partially functional mitochondrial components, making them tentatively attractive for targeting mitochondrial damage. Although direct research on PEVs-mediated mitochondrial rescue remains limited, current evidence suggests that PEVs can modulate diseases associated with mitochondrial dysfunction and potentially enhance mitochondrial health. This review explores the therapeutic potential of PEVs in neurodegenerative and cardiovascular disorders, highlighting their role in restoring mitochondrial health. By examining recent advancements in PEVs research, we aim to shed light on novel strategies for utilizing PEVs as therapeutic agents. Our goal is to underscore the importance of further fundamental and applied research into PEVs-based interventions, as innovative tools for combating a wide range of diseases linked to mitochondrial dysfunction.
MeSH
Extracellular Vesicles, Bioengineering, Mitochondria, Oxidative Stress, Biocompatible Materials, Exosomes, Research, Therapeutics, Blood Platelets