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Journal Article Review Epublish 6 citations

PubMed: 40287777 DOI: 10.1186/s40779-025-00603-5

Exploring the diagnostic potential: magnetic particle imaging for brain diseases.

Mil Med Res 12(1):18

Authors: Li-Shuang Guo, Yu An, Ze-Yu Zhang, Chen-Bin Ma, Jia-Qian Li, Zhen Dong, Jie Tian, Zhen-Yu Liu, Jian-Gang Liu

Affiliations

  • School of Engineering Medicine, Beihang University, Beijing, 100191, China. School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
  • School of Engineering Medicine, Beihang University, Beijing, 100191, China. Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of China, Beijing, 100191, China.
  • School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
  • School of Engineering Medicine, Beihang University, Beijing, 100191, China. Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of China, Beijing, 100191, China. CAS Key Laboratory of Molecular Imaging, Institute of Automation, Beijing, 100191, China.
  • CAS Key Laboratory of Molecular Imaging, Institute of Automation, Beijing, 100191, China. University of Chinese Academy of Sciences, Beijing, 100080, China.
  • School of Engineering Medicine, Beihang University, Beijing, 100191, China.
  • Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of China, Beijing, 100191, China.

Abstract

Brain diseases are characterized by high incidence, disability, and mortality rates. Their elusive nature poses a significant challenge for early diagnosis. Magnetic particle imaging (MPI) is a novel imaging technique with high sensitivity, high temporal resolution, and no ionizing radiation. It relies on the nonlinear magnetization response of superparamagnetic iron oxide nanoparticles (SPIONs), allowing visualization of the spatial concentration distribution of SPIONs in biological tissues. MPI is expected to become a mainstream technology for the early diagnosis of brain diseases, such as cancerous, cerebrovascular, neurodegenerative, and inflammatory diseases. This review provides an overview of the principles of MPI, explores its potential applications in brain diseases, and discusses the prospects for the diagnosis and management of these diseases.

MeSH

Early Diagnosis, Brain, Brain Diseases, Diagnosis, Magnetic Particle Imaging

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