Journal Article Review Ppublish
PubMed: 40289808 DOI: 10.1080/0886022X.2025.2488139
The critical role of ion channels in kidney disease: perspective from AKI and CKD.
Ren Fail 47(1):2488139
Authors: Chen Sui Zi Li, Bing Yu, Qian Gao, Hong Liang Dong, Zhi Ling Li
Affiliations
- Department of Pharmacy, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Shanghai Jiao Tong University School of Medicine, Shanghai, China.
- Department of Pharmacy, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
- Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abstract
Ion channels, particularly those in the transient receptor potential (TRP) family, play key roles in cellular stress responses like inflammation and apoptosis, significantly impacting renal disease progression. Some channels such as TRPV1, TRPM2, TRPC6 impact renal pathology by mediating detrimental calcium influx, exacerbating oxidative stress, and promoting inflammatory pathways. Their activities are especially pronounced in conditions like ischemia and nephrotoxicity, common in acute kidney injury, and persist into chronic kidney injury, influencing fibrosis and nephron loss. Additionally, potassium and sodium channels like Kir4.1, KATP, and ENaC play critical roles in maintaining electrolyte balance and cellular energy under stress conditions. Further exploration of ion channel functionality and regulation is necessary to clarify their roles in renal disease. This review summarizes the involvement of ion channels in AKI and CKD and examines their potential clinical value in diagnosing and treating kidney disease.
MeSH
Kidney Diseases, Stress, Physiological, Kidney, Ion Channels, Uremia, Acute Kidney Injury