Journal Article Review Epublish
PubMed: 40290121 DOI: 10.1016/j.gendis.2024.101481
Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies.
Genes Dis 12(4):101481
Authors: Yixin Song, Kexin Zhang, Jingwen Zhang, Qinying Li, Na Huang, Yujie Ma, Ningning Hou, Fang Han, Chengxia Kan, Xiaodong Sun
Affiliations
- Department of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, China.
- Department of Pathology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, China.
Abstract
The expression and function of the receptor are controlled by epigenetic changes, such as DNA methylation, histone modification, and noncoding RNAs. These modifications play a pivotal role in receptor activity and can lead to or exacerbate endocrine-related diseases. This review examines the epigenetic alterations of nuclear receptors and their significant impact on conditions such as diabetes, thyroid disorders, and endocrine-related tumors. It highlights current therapies targeting these epigenetic mechanisms, including gene editing, epigenetic drugs, and various other therapeutic approaches. This review offers fresh insight into the mechanisms of endocrine-associated disorders, highlighting the latest progress in the development of novel epigenetic therapies that can be used to address receptor-endocrine interactions.
MeSH
Genes, Therapeutics