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Publications

Journal Article Epublish

PubMed: 40313544 DOI: 10.3389/fmed.2025.1567128

Global trends and disparities in the burden of heart failure caused by chronic kidney disease: an analysis of the global burden of disease study 2021.

Front Med (Lausanne) 12:1567128

Authors: Lingxia Ye, Xin Huang, Yufeng Xu

Affiliations

  • Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • Department of Endocrinology and Metabolism, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Municipal Central Hospital, Lishui, China.
  • Department of Ophthalmology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Abstract

Background

Heart failure (HF) is a major public health concern, and chronic kidney disease (CKD) plays a significant role in its pathogenesis. Understanding the trends and disparities in the burden of HF caused by CKD can provide valuable insights into health policymaking.

Methods

This study was a secondary analysis based on previously published data. We obtained global, regional, national, and age- and sex-specific data on the prevalence and years lived with disability (YLDs) of HF caused by CKD from the Global Burden of Disease Study 2021 (GBD 2021) and performed a secondary comparative analysis by age, sex, time, location, sociodemographic index (SDI), and health system level.

Results

In 2021, there were 1,936.9 (95%UI: 1,600.2-2,343.5) thousand cases of HF caused by CKD globally, with an age-standardized rate of YLDs of 3.1 (95%UI: 1.9-4.4) per 100,000 population. The global burden of HF caused by CKD has continuously increased from 1990 to 2021 and is expected to keep growing through 2045 according to predictions. Significant disparities were found across different locations, genders, and ages. Higher burdens were noted among males, older individuals, and regions with lower SDI or less advanced health systems.

Conclusion

The burden of HF caused by CKD has increased significantly since 1990 and varies widely across regions. More significant efforts are needed in the prevention and treatment of CKD and HF, especially among older individuals and males in regions with lower SDI or less advanced health systems.

MeSH

Kidney Diseases, Heart Failure, Heart, Kidney, Global Burden Of Disease, Sex, Cost Of Illness