Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Ppublish
PubMed: 40326805 DOI: 10.1080/17435889.2025.2501919
Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges.
Nanomedicine (Lond) 20(11):1281-1298
Authors: Laura P Rebolledo, Luciana N S Andrade, Marcio C Bajgelman, Lawrence Banks, Xandra O Breakefield, Marina A Dobrovolskaia, Nikolay V Dokholyan, Edna T Kimura, Luisa Villa, Luiz F Zerbini, Valtencir Zucolotto, Kirill A Afonin, Bryan E Strauss, Roger Chammas, Renata de Freitas Saito
Affiliations
- Chemistry and Nanoscale Science Program, Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC, USA.
- Center for Translational Research in Oncology (LIM/24), Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
- Comprehensive Center for Precision Oncology (C2PO), Universidade de Sao Paulo, São Paulo, Brazil.
- Brazilian Biosciences National Laboratory, Center for Research in Energy and Materials, São Paulo, Brazil.
- Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
- Medical School, University of Campinas, São Paulo, Brazil.
- Tumour Virology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
- Molecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
- Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, sponsored by the National Cancer Institute, Frederick Maryland, USA.
- Departments of Pharmacology, and Biochemistry & Molecular Biology, Penn State College of Medicine, Hershey, PA, USA.
- Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
- Department of Radiology and Oncology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
- Department of Cancer Genomics, International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa.
- Integrative Biomedical Sciences Division, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
- Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, São Paulo, Brazil.
Abstract
Different cancers remain major global health challenges due to their diverse biological behaviors and significant treatment hurdles. The aging of populations and lifestyle factors increase cancer occurrence and place increasing pressure on healthcare systems. Despite continuous advancements, many cancers remain fatal due to late-stage diagnosis, tumor heterogeneity, and drug resistance, thus necessitating urgent development of innovative treatment solutions. Therapeutic nucleic acids, a new class of biological drugs, offer a promising approach to overcoming these challenges. The recent Nucleic Acids and Nanobiosystems in Cancer Theranostics (NANCT) conference brought together internationally recognized experts from 15 countries to discuss cutting-edge research, spanning from oncolytic viruses to anticancer RNA nanoparticles and other emerging nanotechnologies. This review captures key insights and developments, emphasizing the need for interdisciplinary translation of scientific advancements into clinical practice and shaping the future of personalized cancer treatments for improved therapeutic outcomes.
MeSH
Extracellular Vesicles, Nanomedicine, Pharmaceutical Preparations, Neoplasms, Nucleic Acids, Viruses, Therapeutics