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Publications

Journal Article Epublish 1 citation

PubMed: 40331097 DOI: 10.3389/fnut.2025.1571473

Delites™ supplementation prevents metabolic syndrome onset and modulates gut microbiome in male Sprague Dawley rats fed on cholesterol- and fat-enriched diet: a randomized preclinical trial study.

Front Nutr 12:1571473

Authors: Juan Leonardo, Robby Hertanto, Reggie Surya, Rony Abdi Syahputra, Wardina Humayrah, Nindy Sabrina, Nurpudji Astuti Taslim, Trina Ekawati Tallei, Raymond Rubianto Tjandrawinata, Fahrul Nurkolis

Affiliations

  • Citra Deli Kreasitama Ltd. Banten, Indonesia.
  • Increase Laboratorium Indonesia, Biomedical Campus BSD City, Tangerang, Banten, Indonesia.
  • Department of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta, Indonesia.
  • Department of Pharmacology, Faculty of Pharmacy, University of North Sumatra, Medan, Indonesia.
  • Nutrition Study Program, Faculty of Food Technology and Health, Sahid University, Jakarta, Indonesia.
  • Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
  • Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia.
  • Faculty of Biotechnology, Center for Pharmaceutical and Nutraceutical Research and Policy, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
  • State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, Indonesia.
  • Master of Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
  • Medical Research Center of Indonesia, Surabaya, East Java, Indonesia.

Abstract

Background

Metabolic syndrome (MetS) is a global health concern, characterized by a combination of dyslipidemia, insulin resistance, obesity, and hypertension, significantly increasing the risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Gut microbiota plays a pivotal role in MetS pathophysiology, with dysbiosis exacerbating metabolic impairments. Delites™, a supplement inspired by Traditional Chinese Medicine, has shown potential in modulating gut microbiota and mitigating MetS.

Objectives

This study aimed to evaluate the effects of Delites™ supplementation on metabolic health and gut microbiota composition in male Sprague Dawley rats fed a cholesterol- and fat-enriched diet (CFED).

Methods

A randomized preclinical trial was conducted on 32 rats divided into four groups: control-normal, CFED, CFED+low-dose Delites™ (54 mg/kg), and CFED+high-dose Delites™ (108 mg/kg). Parameters including lipid profiles, enzymatic activity, molecular biomarkers, and gut microbiota composition were analyzed.

Results

Delites™ significantly improved lipid profiles, reduced inflammation (TNF-), enhanced anti-inflammatory markers (IL-10), and increased energy metabolism regulator PGC-1α. Gut microbiota modulation showed increased beneficial genera (, ) and reduced pathogenic , improving microbial diversity.

Conclusion

Delites™ supplementation effectively mitigates MetS through metabolic and microbiota modulation. These findings highlight its potential for precision medicine approaches to combat metabolic disorders. Further research is needed to explore its long-term effects and translational relevance in humans.

MeSH

Diabetes Mellitus, Dyslipidemias, Diet, Cholesterol, Obesity, Gastrointestinal Microbiome, Metabolic Syndrome, Microbiota, Phytochemicals, Diabetes Mellitus, Type 2