Journal Article Review Epublish
PubMed: 40332051 DOI: 10.3390/ijms26083546
Non-Integrin Laminin Receptors: Shedding New Light and Clarity on Their Involvement in Human Diseases.
Int J Mol Sci 26(8)
Authors: Filomena Napolitano, Maria Fabozzi, Nunzia Montuori
Affiliations
- Department of Translational Medical Sciences, University of Naples Federico II, 80135 Naples, Italy.
- Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80135 Naples, Italy.
Abstract
The extracellular matrix (ECM) is a dynamic network of macromolecules that provides structural support for cells and orchestrates cell signaling, functions, and morphology. The basement membrane constitutes a peculiar sheet-like type of ECM located between epithelial tissues and underlying connective tissues. The major constituent of the basement membrane is laminin, which exerts a remarkable repertoire of biological functions such as cell differentiation, migration, adhesion, and wound healing. Laminin performs its functions by interacting with two main classes of receptors, the integrin and the non-integrin laminin receptors, creating a complex network essential for tissue integrity and regeneration. Dysfunctional actions of laminin are the cause of diverse human diseases, including cancer, infectious, and neurodegenerative diseases. This topic has attracted researchers for some time, but the diversity of cell-surface receptors, through which laminin signaling occurs, makes the role of laminin controversial. Moreover, different laminin isoforms were identified, and each specific tissue basement membrane differs from the others in their laminin composition. This review focuses on the structural and molecular basis and pathophysiological relevance of specific interactions between laminins and non-integrin receptors in development, health, and disease.
MeSH
Cells, Integrins, Receptors, Laminin, Tissues, Basement Membrane, Extracellular Matrix, Laminin, Membranes