Journal Article Review Epublish
PubMed: 40333316 DOI: 10.3390/vaccines13040418
Host-Pathogen Interaction Interface: Promising Candidate Targets for Vaccine-Induced Protective and Memory Immune Responses.
Vaccines (Basel) 13(4)
Authors: Gloria G Guerrero, Vicente Madrid-Marina, Aurora MartÃnez-Romero, Kirvis Torres-Poveda, Juan Manuel Favela-Hernández
Affiliations
- Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas 98600, Zac. Mexico.
- Centro de Investigación en Enfermedades infecciosas (CISEI), Instituto Nacional de Salud Pública (INSP), Cuernavaca 62100, Mor. Mexico.
- Facultad de QuÃmica, Universidad Juárez del Estado de Durango, Gómez Palacio 34100, Dgo. Mexico.
- Secretaria de Ciencia, Humanidades y TecnologÃas (SECIHTI), Instituto Nacional de Salud Pública, Cuernavaca 62100, Mor. Mexico.
- Facultad de QuÃmica, Universidad Juárez del Estado de Durango, Gómez Palacio 34100, Dgo. Mexico. Instituto Multidisciplinario de Ciencias "Avicena", Torreón 27250, Coah. Mexico.
Abstract
Vaccine formulations are a successful strategy against pathogen transmission because vaccine candidates induce effective and long-lasting memory immune responses (B and CD4+ T cells) at systemic and mucosal sites. Extracellular vesicles of lipoproteins, bioactive compounds from plants and invertebrates (sponges) encapsulated in liposomes, and glycoproteins can target these sites. The vaccine candidates developed can mimic microbial pathogens in a way that successfully links the innate and adaptive immune responses. In addition, vaccines plus adjuvants promote and maintain an inflammatory response. In this review, we aimed to identify the host-pathogen interface as a rich source of candidate targets for vaccine-induced protective and long-lasting memory immune responses.
MeSH
Vaccines, Host-Pathogen Interactions, Immunity, Memory