Journal Article Ppublish
PubMed: 40354110 DOI: 10.1099/jmm.0.002011
susceptibility profiles of invasive bloodstream isolates to ten antifungal drugs in a southern area of China.
J Med Microbiol 74(5)
Authors: Qian-Yu Sang, Yun-Hui Liao, Kai-Xuan Huang, Yin-Rong Xie, Yi-Hui Yao, Ping Chen, Xian-Ming Liang
Affiliations
- Department of Clinical Laboratory, Xiamen Hospital of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Xiamen 361000, PR China.
- Centre of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, PR China.
- Clinical Laboratory Branch, Xiamen Association of Integrative Chinese and Western Medicine, Xiamen 361000, PR China.
- Department of Clinical Laboratory, Xiamen Hospital of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Xiamen 361000, PR China. Clinical Laboratory Branch, Xiamen Association of Integrative Chinese and Western Medicine, Xiamen 361000, PR China.
Abstract
In recent years, with the increase of drug resistance of , the incidence rate and mortality of candidemia have gradually increased, which has brought a huge economic and health burden to people. The epidemiological characteristics and antifungal drug sensitivity patterns in different regions have varied. To analyse the distribution and antifungal susceptibility of strains isolated from bloodstreams and provide a basis for the use of antifungal drugs for treatment. A total of 115 strains of were collected from the bloodstream, and 28 strains of colonized were collected from the upper respiratory tract. species were identified using matrix-assisted laser desorption/ionization time-of-flight technology. Antifungal susceptibility was assessed using broth microdilution combined with redox methods. There were eight types of strains isolated from the bloodstream; was the most common species (36.5%), followed by (24.3%), (17.4%) and (14.8%). There was no significant difference in the resistance of to azole drugs between the bloodstream infection group and the upper respiratory tract colonization group, but there was a significant difference in the MIC values of micafungin and fluconazole, with values of 0.017 and 0.003, respectively. Amphotericin B and echinocandins are the most susceptible drugs for all species, but the MICs of echinocandins against are significantly higher than those of other species. (except for ) is highly resistant to azoles, with showing resistance rates of 89.3% and 82.1% to itraconazole and posaconazole, respectively; the resistance rates of are 100% and 94.1%, respectively. remains the predominant pathogen responsible for candidemia. Although the resistance of to antifungals is relatively stable, there are significant differences in the MICs of antifungal drugs against , indicating the importance of strain identification in the treatment of candidemia. For empirical treatment, the use of echinocandin drugs is recommended.
MeSH
Incidence, Pharmaceutical Preparations, Echinocandins, Microbiology, Candidemia, Azoles, Amphotericin B, Therapeutics