Journal Article Epublish
PubMed: 40365493 DOI: 10.3389/fmed.2025.1554723
Impact of vitamin C deficiency on imaging patterns and ventilatory function in pulmonary tuberculosis.
Front Med (Lausanne) 12:1554723
Authors: Ramona Cioboata, Mara Amalia Balteanu, Ovidiu Mircea Zlatian, Silviu Gabriel Vlasceanu, Mircea Vasile Popescu Driga, Denisa Maria Mitroi, Oana Maria Catana, Cezar Ionut Buciu, Georgiana Camen, Adina Andreea Mirea
Affiliations
- Department of Pneumology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
- Department of Pneumology, Victor Babes University Hospital, Craiova, Romania.
- Department of Pulmonology, Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania.
- Department of Microbiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
- Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
- Doctoral School, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
- Department of Radiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
- Department of Oral-Dental Prevention, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Abstract
Background
Studies have shown that vitamin C is essential for the immune response to tuberculosis (TB), and that its deficiency may elevate the risk of TB and related complications. This prospective study investigated the association between disease severity, imaging findings and vitamin C levels.
Methods
This study enrolled 109 patients with confirmed pulmonary tuberculosis based on culture. Patients were divided into two groups based on serum vitamin C levels: 59 patients (54.13%) with normal levels and 50 (45.87%) with low levels.
Results
At baseline, patients in the low vitamin C group showed significantly higher bacillar loads, with 86.00% presenting loads of 2+ or higher compared with 59.32% in the normal group ( < 0.001). After 2 months of treatment, 83.05% of the normal vitamin C group achieved culture conversion, while only 28.00% of the low vitamin C group reached the same milestone ( < 0.001). CT imaging at baseline revealed that the low vitamin C group had a significantly higher mean frequency of the tree-in-bud pattern (2.66 vs. 2.05; < 0.001). Cavitary lesions were more prevalent in the low vitamin C group, in the superior right lobe (0.34 vs. 0.13; = 0.011) and superior left lobe (0.34 vs. 0.14; = 0.012). After 6 months of treatment, the low vitamin C group exhibited a higher prevalence of bronchiectasis (mean involvement in both lungs: 0.58 vs. 0.16; < 0.001), cavitary lesions (0.32 vs. 0.00; = 0.002), and fibrosis (0.90 vs. 0.36; < 0.001). Pulmonary function tests showed greater impairment in the low vitamin C group. The forced expiratory volume decreased by 5.77% compared to 3.59% in the normal group ( < 0.001), the forced vital capacity (FVC) decreased by 12.00% vs. 6.67% ( < 0.001), and the Tiffeneau index by 3.34 vs. 2.13 ( = 0.002). Receiver operating characteristic (ROC) analysis indicated that FVC (AUC = 0.826) and forced expiratory flow (AUC = 0.745) were stronger predictors of treatment success in patients with normal vitamin C levels.
Conclusion
Vitamin C deficiency is correlated with increased disease severity, delayed bacterial clearance, and persistent pulmonary damage in patients with tuberculosis. Vitamin C supplementation can enhance treatment outcomes in tuberculosis therapy.
MeSH
Tuberculosis, Pulmonary, Vitamins, Ascorbic Acid, Spirometry, Tuberculosis, Ascorbic Acid Deficiency, Therapeutics, Wounds And Injuries, Vital Capacity