Journal Article Epublish 1 citation
PubMed: 40370837 DOI: 10.3389/fvets.2025.1594239
Resveratrol inhibits the formation of Staphylococcus aureus biofilms by reducing PIA, eDNA release, and ROS production.
Front Vet Sci 12:1594239
Authors: Jinfei He, Yilong Cui, Yan Liu, Jingdong Mao, Yanxin Dong, Ruizhi Yao, Dahan Yang, Peichao Fan, Jiangdong Xue
Affiliations
- College of Animal Science and Technology, Inner Mongolia MINZU University, Tongliao, China.
- College of Life Sciences and Food Engineering, Inner Mongolia MINZU University, Tongliao, China.
Abstract
Introduction
Staphylococcus aureus is a zoonotic pathogen that is difficult to control. Resveratrol (RES) has been shown to have significant antibacterial effects. The present study aimed to investigate the inhibitory effect of RES on the formation of Staphylococcus aureus biofilms and their molecular mechanism.
Methods
First, the minimum inhibitory concentration and inhibitory action curve of RES against Staphylococcus aureus were obtained through testing. Second, we found that RES can inhibit biofilm formation by reducing the release of polysaccharide intercellular adhesion (PIA) and extracellular DNA (eDNA) from Staphylococcus aureus.
Results
RES treatment significantly reduced the production of reactive oxygen species (ROS) and nicotinamide adenine dinucleotide phosphate (NADPH) in Staphylococcus aureus, indicating that ROS and NADPH are closely related to biofilm formation.
Conclusion
This study demonstrates that RES inhibits the formation of Staphylococcus aureus biofilms by reducing PIA, eDNA release, and ROS production, and these results provide new ideas for the clinical application of RES in the treatment of Staphylococcus aureus infection.
MeSH
Staphylococcus, Nadp, Biofilms, Staphylococcus Aureus, Therapeutics, Resveratrol