Journal Article Epublish
PubMed: 40397919 DOI: 10.1371/journal.pone.0323172
Metabolic and immune heterogeneity in stroke: Insights into subtype identification and biomarker discovery.
PLoS One 20(5):e0323172
Authors: Wei Wang, Qiuyang Qian, Ziye Guo, Fangyi Lin, Weiming Lin, Zhigang Yuan, Mei Shen
Affiliations
- Rehabilitation Medicine Department, Shenzhen Longhua District People's Hospital, Shenzhen, China.
- Department of Critical Care Medicine, Shenzhen Longhua District People's Hospital, Shenzhen, China.
Abstract
Stroke is a leading cause of mortality and long-term disability worldwide, characterized by substantial molecular and clinical heterogeneity. This study aimed to investigate the metabolic and immune-related mechanisms underlying stroke subtypes using transcriptomic data and advanced computational tools. Gene expression data from two GEO datasets (GSE16561 and GSE58294) were preprocessed, batch-corrected, and integrated. Consensus clustering based on 2,752 metabolism-related genes identified three distinct subtypes with significant differences in metabolic activity. GSVA analysis revealed subtype-specific variations in key pathways, such as the citrate cycle, glycolysis, and glycosaminoglycan biosynthesis, highlighting their metabolic diversity.
MeSH
Genes, Stroke, Biomarkers