Journal Article Review Epublish
PubMed: 40430956 DOI: 10.3390/pharmaceutics17050666
Exploring the Analgesic Potential of L-Lysine: Molecular Mechanisms, Preclinical Evidence, and Implications for Pharmaceutical Pain Therapy.
Pharmaceutics 17(5)
Authors: Walaa Alibrahem, Nihad Kharrat Helu, Gréta Törős, Csaba Oláh, József Prokisch
Affiliations
- Doctoral School of Health Sciences, University of Debrecen, Egyetem Tér 1, 4028 Debrecen, Hungary.
- Institute of Animal Science, Biotechnology and Nature Conservation, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.
- Doctoral School of Animal Husbandry, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.
- Mathias Institute, University of Tokaj, Eötvös Str. 7, 3950 Sárospatak, Hungary.
- Neurosurgery Department, Borsod County University Teaching Hospital, Szentpéteri Kapu 72-76, 3526 Miskolc, Hungary.
Abstract
Pain is a complex, multifaceted sensory-emotional state. It still poses a significant challenge in clinical treatment, especially in cases of chronic pain. Concerns associated with the use of opioids as analgesics have led to the search for new and safer pain relievers. This review examines the potential of lysine in pain control by exploring its molecular mechanisms and the preclinical evidence and clinical implications. Lysine has demonstrated analgesic effects by inhibiting NMDA receptors, modulating dopamine and serotonin pathways, and interfering with neuroimmune signaling cascades. Studies in animal models have shown that the administration of lysine reduces pain responses without altering motor function. Despite the favorable profile of lysine in terms of minor side effects and its promising effectiveness as a nutritional supplement, more research is needed to optimize its efficacy, adjust its dosage, and ensure its safety for long-term use.
MeSH
Fibromyalgia, Chronic Pain, Pain, Pharmaceutical Preparations, Pain Management, Dopamine, Analgesia, Analgesics, Therapeutics, Synaptic Transmission, Lysine