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Journal Article Review Ppublish 14 citations

PubMed: 40443365 DOI: 10.1093/jimmun/vkae036

Immunological biomarkers of aging.

J Immunol 214(5):889-902

Authors: Fei Wu, Wei-Chieh Mu, Nikola T Markov, Matias Fuentealba, Heather Halaweh, Fiona Senchyna, Max N Manwaring-Mueller, Daniel A Winer, David Furman

Affiliations

  • Buck AI Platform, Buck Institute for Research on Aging, Novato, CA, United States.
  • Diabetes Research Group, Division of Cellular and Molecular Biology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
  • Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.
  • Buck Institute for Research on Aging, Novato, CA, United States.
  • Department of Immunology, University of Toronto, Toronto, ON, Canada.
  • Stanford 1000 Immunomes Project, Stanford University School of Medicine, Stanford, CA, United States.

Abstract

The immune system has long been recognized for its critical role in the elimination of pathogens and the development of autoimmune diseases, but recent evidence demonstrates that it also contributes to noncommunicable diseases associated with biological aging processes, such as cancer, cardiovascular disease, neurodegeneration, and frailty. This review examines immunological biomarkers of aging, focusing on how the immune system evolves with age and its impact on health and disease. It discusses the historical development of immunological assessments, technological advancements, and the creation of novel biomarkers and models to study immune aging. We also explore the clinical implications of immune aging, such as increased susceptibility to infectious diseases, poor vaccine responses, and a higher incidence of noncommunicable diseases. In summary, we provide a comprehensive overview of current research, highlight the clinical relevance of immune aging, and identify gaps in knowledge that require further investigation.

MeSH

Aging, Immunosenescence, Noncommunicable Diseases, Biomarkers, Immune System

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