Journal Article Review Ppublish
PubMed: 40452274 DOI: 10.3347/PHD.24086
Therapeutic potentials of Trichinella spiralis in immune disorders: From allergy to autoimmunity.
Parasites Hosts Dis 63(2):123-134
Authors: Minkyoung Cho, Hak Sun Yu
Affiliations
- Department of Parasitology and Tropical Medicine, Institute of Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea. Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
- Department of Parasitology and Tropical Medicine, School of Medicine, Pusan National University, Yangsan 50612, Korea. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea.
Abstract
The incidence of immune system diseases is increasing globally, particularly in developed countries. The hygiene and old friend hypotheses suggest that the decreased incidence of helminth infections in these countries may underlie the rising prevalence of autoimmune, allergic, and inflammatory diseases. The preventive and therapeutic potential of Trichinella spiralis, a helminthic parasite, has been well demonstrated in animal models of immune dysregulation-mediated diseases. This review comprehensively analyze how T. spiralis modulates immune responses across a spectrum of immune dysregulation. We systematically review the key research findings on the effects of T. spiralis infection on immune-related disease. T. spiralis has shown the ability to regulate host immune responses in autoimmune, allergic, and inflammatory disorders, exerting anti-inflammatory effects and restoring immune homeostasis through various immunological pathways. Given its significant immunomodulatory potential, T. spiralis represents a promising candidate for therapeutic interventions against immune-mediated diseases, warranting further molecular investigations and clinical applications.
MeSH
Incidence, Hypersensitivity, Immune System Diseases, Immunity, Autoimmune Diseases, Therapeutics, Infections, Autoimmunity, Allergy