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Publications

Journal Article Review Ppublish

PubMed: 40452566 DOI: 10.1002/cnr2.70210

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential.

Cancer Rep (Hoboken) 8(6):e70210

Authors: Sumaira Anjum, Mariam Hashim, Maham Imran, Sundus Babur, Sanniah Adnan, Christophe Hano, Wisam Nabeel Ibrahim

Affiliations

  • Department of Biotechnology, Kinnaird College for Women, Lahore, Pakistan.
  • Laboratoire de Biologie Des Ligneux et Des Grandes Cultures, INRAE USC1328, Eure & Loir Campus, University of Orleans, Chartres, France.
  • Department of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.

Abstract

BACKGROUND

Cancer represents a complex group of diseases characterized by abnormal cell proliferation, invasion, and metastasis. These features pose significant challenges to conventional therapeutic approaches, necessitating the development of more targeted and effective treatment strategies.

OBJECTIVE

This review aims to explore the potential of selenium nanoparticles (SeNPs) as a novel therapeutic tool in cancer treatment, emphasizing their cytotoxic mechanisms and advantages over conventional therapies and other nanoparticles.

METHODS

The review synthesizes findings from recent studies investigating the therapeutic properties of SeNPs in cancer models. Emphasis is placed on their ability to selectively target malignant cells, modulate redox status, and influence tumor-associated cellular processes such as autophagy and microRNA regulation.

RESULTS

SeNPs demonstrate intrinsic antioxidant properties that counteract oxidative stress commonly observed in cancer cells. They modulate critical cellular pathways and exhibit selective toxicity, damaging cancer cells while sparing healthy tissues. Additionally, their biocompatibility and capacity to deliver therapeutic agents contribute to improved safety and efficacy compared to other nanoparticle platforms.

CONCLUSION

Selenium nanoparticles hold significant promise as a next-generation cancer treatment modality. Their dual function-serving as both therapeutic agents and drug delivery vehicles-positions them as a powerful tool in precision oncology. By minimizing off-target effects and enhancing targeted drug delivery, SeNPs have the potential to advance the landscape of cancer theragnostics.

MeSH

Cells, Selenoproteins, Nanoparticles, Pharmaceutical Preparations, Neoplasms, Oxidative Stress, Therapeutics

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