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Publications

Journal Article Review Epublish

PubMed: 40453080 DOI: 10.3389/fimmu.2025.1557402

New insights into the role of cellular senescence and rheumatic diseases.

Front Immunol 16:1557402

Authors: Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang

Affiliations

  • Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China.
  • Institute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, Anhui, China.
  • Anhui Province Key Laboratory of Modern Chinese Medicine, Department of Internal Medicine Application Foundation Research and Development, Hefei, Anhui, China.
  • Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China. Institute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, Anhui, China. Anhui Province Key Laboratory of Modern Chinese Medicine, Department of Internal Medicine Application Foundation Research and Development, Hefei, Anhui, China.
  • Institute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, Anhui, China. Anhui Province Key Laboratory of Modern Chinese Medicine, Department of Internal Medicine Application Foundation Research and Development, Hefei, Anhui, China.

Abstract

Rheumatic disease is a chronic inflammatory disease that imposes significant societal and economic burdens. Accumulating evidence has demonstrated that cellular senescence plays an important role in inflammation-induced rheumatic diseases. Due to the lack of effective therapies, there is an urgent need for a deeper understanding of the etiopathogenesis of rheumatic diseases. In this review, we systematically summarized the role of cellular senescence in rheumatic diseases. We first focused on the mechanisms and hallmarks of cellular senescence, and then summarized evidence that can induce or aggravate cellular senescence, as well as related signaling pathways. Next, we discussed the mechanisms of interaction between cellular senescence and rheumatic diseases. Additionally, we focused on and elucidated the mechanisms and impacts of chondrocyte senescence and mesenchymal stem cell (MSC) senescence in osteoarthritis (OA) and systemic lupus erythematosus (SLE), respectively. Finally, we highlighted the potential of therapies targeting senescent cells in rheumatic diseases as a strategy, especially the multi-target effect of traditional Chinese medicine.

MeSH

Cells, Microscopy, Electron, Scanning Transmission, Cellular Senescence, Rheumatic Diseases, Immune System Diseases, Therapeutics