Journal Article Systematic Review Epublish
PubMed: 40453586 DOI: 10.3389/fendo.2025.1541744
Review of Mendelian randomization studies on common male-specific diseases.
Front Endocrinol (Lausanne) 16:1541744
Authors: Qixin Pang, Zhe Chang, Hao Liu, Jianshe Chen, Sicheng Ma, Chenming Zhang, Zixue Sun
Affiliations
- Traditional Chinese Medicine (ZHONG JING) School, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
- School of Foreign Languages, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
- Queen Mary College, Nanchang University, Nanchang, Jiangxi, China.
- Reproductive Medicine Department, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China.
- The Second Clinical Medical School, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
Abstract
Although numerous Mendelian randomization studies on risk factors have been conducted in male medicine, a systematic synthesis of these findings is still lacking. This review searched relevant literature in PubMed and the Web of Science published before May 2024; systematically summarized the progress in the application of Mendelian randomization in male infertility, erectile dysfunction, prostate cancer, and prostatitis; summarized and classified the risk factors affecting men's health, such as the gut microbiota, modifiable risk factors and related diseases; and presented some problems and solutions that were presented in these studies. This information offers valuable insights into the etiology and pathogenesis of male-specific diseases.
MeSH
Erectile Dysfunction, Prostatitis, Prostatic Neoplasms, Risk Factors, Infertility, Male, Random Allocation