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Publications

Journal Article Review Ppublish 37 citations

PubMed: 40454774 DOI: 10.1111/jnc.70084

Neural Metabolic Networks: Key Elements of Healthy Brain Function.

J Neurochem 169(6):e70084

Authors: Nimrod Madrer, Nirma D Perera, Nonthué A Uccelli, Alice Abbondanza, Jens V Andersen, Emma Veronica Carsana, Matthew D Demmings, Regina F Fernandez, Matheus Garcia de Fragas, Ismail Gbadamosi, Divita Kulshrestha, Ricardo A S Lima-Filho, Oana C Marian, Kia H Markussen, Andrew J McGovern, Elliott S Neal, Sukanya Sarkar, Eva Šimončičová, Jazmín Soto-Verdugo, Sozerko Yandiev, Ignacio Fernández-Moncada

Affiliations

  • The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
  • Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Laboratory of Neurochemistry, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
  • Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
  • Università Degli Studi di Milano, Milan, Italy.
  • Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
  • The Michael V. Johnston Center for Developmental Neuroscience, Kennedy Krieger Institute, Baltimore, Maryland, USA.
  • Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Department of Immunology, Instituto de Ciências Biomédicas (ICB IV), Universidade de São Paulo, São Paulo, SP, Brazil.
  • Laboratory for Translational Research in Neuropsychiatric Disorders (TREND), BRAINCITY-Center of Excellence for Neural Plasticity and Brain Disorders, Institute of Experimental Biology Marceli Nencki. Polish Academy of Sciences, Warsaw, Poland.
  • Łukasiewicz Research Network-PORT, Polish Center for Technology Development, Wroclaw, Poland.
  • Department of Biology, Technische Universität Dresden, Dresden, Germany.
  • Institute of Medical Biochemistry Leopoldo De Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Charles Perkins Centre, School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia.
  • Deparment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentuchy, Lexington, Kentuchy, USA.
  • Department of Biological Sciences, University of Limerick, Limerick, Ireland.
  • School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia.
  • Department of Cell Biology and Physiology, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
  • Department of Neurology, Columbia University Irving Medical Centre, New York, New York, USA.
  • Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.
  • Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
  • Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México.
  • Univ. Lyon, Université Claude Bernard Lyon 1, CNRS, INSERM, Physiopathologie et Génétique du Neurone et du Muscle, UMR5261, U1315, Institut NeuroMyoGène, Lyon, France.
  • Univ. Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000 Bordeaux, France.
  • Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, Bordeaux, France.

Abstract

Neural networks are responsible for processing sensory stimuli and driving the synaptic activity required for brain function and behavior. This computational capacity is expensive and requires a steady supply of energy and building blocks to operate. Importantly, the neural networks are composed of different cell populations, whose metabolic profiles differ between each other, thus endowing them with different metabolic capacities, such as, for example, the ability to synthesize specific metabolic precursors or variable proficiency to manage their metabolic waste. These marked differences likely prompted the emergence of diverse intercellular metabolic interactions, in which the shuttling and cycling of specific metabolites between brain cells allows the separation of workload and efficient control of energy demand and supply within the central nervous system. Nevertheless, our knowledge about brain bioenergetics and the specific metabolic adaptations of neural cells still warrants further studies. In this review, originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School held in Schmerlenbach, Germany (2022), we describe and discuss the specific metabolic profiles of brain cells, the intercellular metabolic exchanges between these cells, and how these bioenergetic activities shape synaptic function and behavior. Furthermore, we discuss the potential role of faulty brain metabolic activity in the etiology and progression of Alzheimer's disease, Parkinson disease, and Amyotrophic lateral sclerosis. We foresee that a deeper understanding of neural networks metabolism will provide crucial insights into how higher-order brain functions emerge and reveal the roots of neuropathological conditions whose hallmarks include impaired brain metabolic function.

MeSH

Cells, Astrocytes, Neurons, Parkinson Disease, Brain, Mitochondria

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