Journal Article Review Ppublish 1 citation
PubMed: 40457168 DOI: 10.1111/febs.70139
A guide to heat shock factors as multifunctional transcriptional regulators.
FEBS J 292(16):4133-4155
Authors: Hendrik S E Hästbacka, Alejandro J Da Silva, Lea Sistonen, Eva Henriksson
Affiliations
- Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Turku, Finland. Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.
- Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Turku, Finland.
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.
Abstract
The heat shock factors (HSFs) form a family of transcription factors, which are evolutionarily conserved in eukaryotes. They are best known as transcriptional regulators of molecular chaperone genes, including those encoding heat shock proteins, in response to heat shock and other protein-damaging stresses. Since the discovery of the first HSF and its eponymous role in the heat shock response four decades ago, the currently known HSFs in vertebrates, that is, HSF1-5, HSFX, and HSFY, have been implicated in a wide array of physiological and pathological processes, including organismal development and cancer progression. To date, most studies have focused on individual HSFs, but it is becoming increasingly evident that the role of multiple HSFs and their potential crosstalk should be considered. In this review, we provide a comprehensive overview of the structures, functions, and regulation of the mammalian HSF family members and explore their interplay in biological processes. We highlight recent advancements regarding the roles of HSF family members in viral infection, cell adhesion, and spermatogenesis, and discuss the key questions to be addressed by forthcoming studies in HSF biology.
MeSH
Tissue Adhesions, Genes, Biochemistry, Stress, Physiological, Neoplasms, Spermatogenesis