Journal Article Ppublish
PubMed: 40457642 DOI: 10.1002/mrm.30571
Quantitative susceptibility mapping in the human brain at 7T with phase-cycled balanced SSFP.
Magn Reson Med 94(4):1469-1484
Authors: Berk Can Acikgoz, Cristina Sainz Martinez, Adèle L C Mackowiak, Nils M J Plähn, Yasaman Safarkhanlo, Eva S Peper, Piotr Radojewski, Gabriele Bonanno, João Jorge, Jessica A M Bastiaansen
Affiliations
- Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
- Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland.
- Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
- CSEM - Swiss Center for Electronics and Microtechnology, Bern, Switzerland.
- CIBM Center for Biomedical Imaging, Lausanne, Switzerland.
- Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
- Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
- Department of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.
- Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Bern, Switzerland.
Abstract
PURPOSE
To demonstrate the feasibility of QSM and to show the potential of simultaneous , , and proton density (PD) mapping in the human brain at 7T based on phase-cycled balanced SSFP (bSSFP) MRI.
METHODS
An algorithm was developed to estimate off-resonance frequency in multi-compartment scenarios by combining elliptic phase-cycled bSSFP signal fitting with dictionary matching. Phase-cycled bSSFP-based tissue phase and susceptibility maps were compared with multi-echo gradient-echo (MEGRE)-based maps in the brains of eight healthy subjects at 7T. Additionally, , , and PD maps were obtained from the same phase-cycled bSSFP data. To demonstrate the potential of matching scan time with MEGRE, bSSFP profiles were subsampled by 50% and resulting maps compared with the reference data.
RESULTS
The tissue phase maps obtained from phase-cycled bSSFP data agreed well with the reference, with a mean absolute deviation of Hz in the entire brain of all subjects. The mean absolute deviation of tissue susceptibility was parts-per-billion (ppb). Susceptibility in the globus pallidus was overestimated by 67 ppb (p < 0.05), while no significant biases were observed in other regions: 3.2 ppb in putamen, 15.5 ppb in thalamus, and 11.9 ppb in caudate nucleus (all p > 0.05). Quantitative maps showed good contrast between different regions of the brain, aligning well with the literature. Profile subsampling did not significantly (p > 0.05) change the quantitative susceptibility maps.
CONCLUSION
The feasibility of phase-cycled bSSFP for QSM at 7T was demonstrated, with the added benefit of simultaneous , , and PD mapping, with a total scan time of ˜20 min.
MeSH
Brain, Multiple Chronic Conditions, Tissues, Quantitative Susceptibility Mapping