Journal Article Review Epublish
PubMed: 40458607 DOI: 10.1155/ijbm/5533798
Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine Applications.
Int J Biomater 2025:5533798
Authors: Syed Muhammad Hasan, Saadat Hussain, Muhammad Yousuf, José Agustín Tapia-Hernández, Daim Asif Raja
Affiliations
- Memon Medical Institute Hospital, Karachi, Pakistan.
- H.E.J Research Institute of Chemistry, ICCBS, University of Karachi, Karachi 75270, Pakistan.
- Department of Biomedical and Biological Sciences, Sohail University, Karachi 74000, Pakistan.
- Department of Food Research and Graduate Program, University of Sonora, C.P. 83000, Hermosillo, Sonora, Mexico.
Abstract
Nanotechnology has emerged as a transformative field in recent years, greatly impacting medicine and healthcare with innovative solutions for complex diseases. Among these advancements, protein-based metal nanoparticles have shown exceptional promise in treating chronic illnesses, owing to their high biocompatibility, biodegradability, customizable surface properties, and precise drug delivery capabilities. Recent studies have highlighted advancements in targeting efficiency and controlled release, alongside the ability of protein-based metal nanoparticles to bypass the first-pass metabolism, enhancing bioavailability through novel administration routes. Cutting-edge research has also focused on functionalizing protein nanostructures with therapeutic metal ions, particularly silver, with a longstanding antimicrobial and anti-inflammatory history. New combinations of silver with protein-based nanoparticles are now showing significant potential in managing chronic and life-threatening conditions. This review provides a comprehensive overview of the latest synthesis methods, toxicity assessments, therapeutic applications, administration pathways, and advanced characterization techniques for protein-based silver nanoparticles, addressing the evolving landscape of nanomedicine.
MeSH
Chronic Disease, Nanomedicine, Nanoparticles, Metal Nanoparticles, Therapeutics