System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Preprint Epublish

PubMed: 40463267 DOI: 10.1101/2025.05.01.651544

An open, fully-processed data resource for studying mood and sleep variability in the developing brain.

bioRxiv

Authors: Juliette B H Brook, Taylor Salo, Audrey C Luo, Joƫlle Bagautdinova, Sage Rush, Aaron F Alexander-Bloch, Erica B Baller, Monica E Calkins, Matt Cieslak, Elena C Cooper, John A Detre, Mark A Elliot, Damien A Fair, Phoebe Freedman, Philip R Gehrman, Ruben C Gur, Raquel E Gur, Arno Klein, Nina Laney, Timothy O Laumann, Kahini Mehta, Kathleen Merikangas, Michael P Milham, Jonathan A Mitchell, Tyler M Moore, Steven M Nelson, Kosha Ruparel, Brooke L Sevchik, Sheila Shanmugan, Haochang Shou, Manuel Taso, Lauren K White, Daniel H Wolf, M Dylan Tisdall, David R Roalf, Theodore D Satterthwaite

Affiliations

  • Department of Psychiatry, University of Pennsylvania, Philadelphia, PA.
  • Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Philadelphia, PA.
  • Lifespan Brain Institute, Penn Medicine and Children's Hospital of Philadelphia, Philadelphia, PA.
  • Department of Child and Adolescent Psychiatry and Behavioral Science, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Department of Neurology, University of Pennsylvania, Philadelphia, PA.
  • Department of Radiology, University of Pennsylvania, Philadelphia, PA.
  • Institute of Child Development, University of Minnesota, Minneapolis, MN.
  • University of Minnesota Department of Pediatrics, Minneapolis, MN.
  • Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN.
  • Child Mind Institute, New York, NY.
  • Department of Psychiatry, Washington University in St. Louis, St. Louis, MO.
  • Department of Neuroscience, Columbia University, New York, NY.
  • Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD.
  • Center for the Developing Brain, Child Mind Institute, New York, NY.
  • Nathan S. Kline Institute for Psychiatric Research, New York City, NY.
  • Department of Pediatrics, University of Pennsylvania, Philadelphia, PA.
  • Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Center for AI and Data Science for Integrated Diagnostics (AI2D), University of Pennsylvania, Philadelphia, PA.
  • Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, & Informatics, University of Pennsylvania, Philadelphia, PA.
  • Siemens Medical Solutions USA Inc, Malvern, PA.
  • Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA.

Abstract

Brain development during adolescence and early adulthood coincides with shifts in emotion regulation and sleep. Despite this, few existing datasets simultaneously characterize affective dynamics, sleep variation, and multimodal measures of brain development. Here, we describe the study protocol and initial release (n = 10) of an open data resource of neuroimaging paired with densely sampled behavioral measures in adolescents and young adults. All participants complete multi-echo functional MRI, compressed-sensing diffusion MRI, and advanced arterial spin-labeled MRI. Behavioral measures include ecological momentary assessment, actigraphy, extensive cognitive assessments, and detailed clinical phenotyping focused on emotion regulation. Raw and processed data are openly available without a data use agreement and will be regularly updated as accrual continues. Together, this resource will accelerate research on the links between mood, sleep, and brain development.

MeSH

Emotions, Sleep, Brain, Multiple Chronic Conditions, Emotional Regulation