Journal Article Review Epublish
PubMed: 40463912 DOI: 10.3389/fncel.2025.1588645
Role of mitochondrial quality control in neurodegenerative disease progression.
Front Cell Neurosci 19:1588645
Authors: Tingting Liu, Weibo Sun, Shuhao Guo, Zhiying Yuan, Minghang Zhu, Jing Lu, Tao Chen, Yuanyuan Qu, Chuwen Feng, Tiansong Yang
Affiliations
- Heilongjiang University of Chinese Medicine, Harbin, China.
- Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
- Rehabilitation Department II, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
- Heilongjiang University of Chinese Medicine, Harbin, China. Rehabilitation Department II, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China. Key Laboratory of Chinese Medicine Informotics in Heilongjiang Province, Harbin, China.
- Key Laboratory of Chinese Medicine Informotics in Heilongjiang Province, Harbin, China.
Abstract
Neurodegenerative diseases are a diverse group of neurological disorders, in which abnormal mitochondrial function is closely associated with their development and progression. This has generated significant research interest in the field. The proper functioning of mitochondria relies on the dynamic regulation of the mitochondrial quality control system. Key processes such as mitochondrial biogenesis, mitophagy, and mitochondrial dynamics (division/fusion) are essential for maintaining this balance. These processes collectively govern mitochondrial function and homeostasis. Therefore, the mitochondrial quality control system plays a critical role in the onset and progression of neurodegenerative diseases. This article provides a concise overview of the molecular mechanisms involved in mitochondrial biogenesis, mitophagy, and mitochondrial dynamics, explores their interactions, and summarizes current research progress in understanding the mitochondrial quality control system in the context of neurodegenerative diseases.
MeSH
Quality Control, Disease Progression, Mitochondria, Mitochondrial Dynamics, Organelle Biogenesis, Amyotrophic Lateral Sclerosis, Research, Mitophagy, Neurodegenerative Diseases