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Publications

Journal Article Review Case Reports Epublish

PubMed: 40465890 DOI: 10.1590/0037-8682-0008-2025

Cytogenetic Alterations Observed in Exfoliative Cells of the Tongue and Oral Mucosa of SARS-CoV-2-Vaccinated Patients: Report of Two Cases and a Brief Literature Review.

Rev Soc Bras Med Trop 58:e008042025

Authors: Lucas Alves da Mota Santana, Michelly Kierkegaard Campos de Oliveira, Maria Vitória Conceição Carvalho, Pedro Henrique Macedo Moura, Marina Dos Santos Barreto, Marcos Antônio Lima Dos Santos, Pedro Lima Dos Santos, Dalmo Correia, Virgínia Kelma Dos Santos Silva, Rajiv Gandhi Gopalsamy, Cleverson Luciano Trento, Lysandro Pinto Borges, Wilton Mitsunari Takeshita

Affiliations

  • Universidade Federal de Sergipe, Departmento de Odontologia, Aracaju, SE, Brasil.
  • Universidade Tiradentes, Departamento de Odontologia, Aracaju, SE, Brasil.
  • Universidade Federal de Sergipe, Departmento de Farmácia, São Cristóvão, SE, Brasil.
  • Universidade de São Paulo, Faculdade de Odontologia, Departamento de Estomatologia, São Paulo, SP, Brasil.
  • Universidade Federal de Sergipe, Departamento de Medicina, Laboratório de Patologia, Aracaju, SE, Brasil.
  • Universidade Federal de Sergipe, Departmento de Medicina, Aracaju, SE, Brasil.
  • Universidade Federal de Sergipe, Programa de Pós-Graduação em Ciências da Saúde, Aracaju, SE, Brasil.
  • Universidade Tiradentes, Departamento de Medicina, Aracaju, SE, Brasil.
  • Rajagiri College of Social Sciences, Division of Phytochemistry and Drug Design, Department of Biosciences, Kochi, Kerala, India.
  • Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Odontologia, Departamento de Diagnóstico e Cirurgia, Araçatuba, SP, Brasil.

Abstract

The wide distribution of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) in oral tissues, especially in the salivary glands, which are natural reservoirs of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contributes to the classification of the oral cavity as a potential target for the development of lesions. Despite the effective response produced by next-generation immunizers, the possibility of immune escape by new lineages of SARS-CoV-2 cannot be refuted. Therefore, we describe here the occurrence of cytogenetic alterations in orally exfoliated cells of immunized individuals and, based on the literature review, call attention to the need to monitor these cases in the post-pandemic period.

MeSH

Cells, Sars-Cov-2, Tongue, Vaccines, Mouth Mucosa, Tropical Medicine, Cytogenetics, Severe Acute Respiratory Syndrome-Related Coronavirus, Mucous Membrane