Journal Article Review Epublish 12 citations
PubMed: 40470272 DOI: 10.3389/fvets.2025.1571373
Physiological factors affecting platelet-rich plasma variability in human and veterinary medicine.
Front Vet Sci 12:1571373
Authors: Rocío Colomer-Selva, Asta Tvarijonavciute, Lorena Franco-Martínez, Ángel María Hernández-Guerra, José María Carrillo, Mónica Rubio, Joaquín Jesús Sopena, Katy Satué
Affiliations
- Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, CEU Cardenal Herrera University, CEU Universities, Valencia, Spain.
- Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence "Campus MareNostrum", University of Murcia, Murcia, Spain.
- García Cugat Foundation CEU-UCH Chair of Medicine and Regenerative Surgery, CEU Cardenal Herrera University, CEU Universities, Valencia, Spain.
Abstract
Platelet-rich plasma (PRP) is the fraction of autologous plasma that contains a supraphysiological concentration of platelets, which are an important reservoir of growth factors. PRP is today one of the treatments of choice in regenerative medicine in both humans and animals. The aim of this study was to assess the existing literature on the possible influence of the patient's physiological factors on different PRP characteristics, like platelet concentration, quantity of obtained plasma, quantity and types of growth factors (GFs) in human and veterinary medicines. In addition, a secondary aim was to compare protocols used to prepare PRP in these studies. In a total of 34 studies evaluated, the use of different protocols for the preparation and characterization of PRP and certain physiological factors such as age, sex and body condition substantially modify the characteristics of PRP in both human and veterinary medicine. Therefore, it is essential to standardize PRP collection protocols and define study groups based on physiological factors like sex, age, body mass index, fertility status and analyzed GFs to ensure reliable data and derive precise, informative conclusions.
MeSH
Platelet-Rich Plasma, Growth, Regenerative Medicine, Veterinary Medicine, Sex, Blood Platelets, Plasma