Journal Article Ppublish
PubMed: 40470712 DOI: 10.1002/biof.70027
Unlocking the Antiadipogenic Potential of Carotenoids From Galdieria phlegrea.
Biofactors 51(3):e70027
Authors: Enrica Giustino, Paola Imbimbo, Jenifer Trepiana, Maria Puy Portillo, Daria Maria Monti
Affiliations
- Department of Chemical Sciences, University of Naples Federico II, Naples, Italy.
- Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Center, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain.
- CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
- BIOARABA Health Research Institute, Vitoria-Gasteiz, Spain.
Abstract
Oxidative stress, a sedentary and inactive lifestyle, or a high-fat diet are among the main causes responsible for the alteration of skin topography, a complex multifactorial disorder of the deeper layers of the skin, mainly caused by an impairment of lipid production, degradation, and storage. Natural bioactive compounds can improve skin health and appearance as well as reassure consumers' about the safety of the molecules used in cosmetics. Carotenoids from microalgae are receiving attention because of their potent antioxidant activity. Here, a carotenoid extract from Galdieria phlegrea residual biomass was successfully explored for its ability to inhibit in vitro skin hyperpigmentation, to interfere with 3T3-L1 adipocytes differentiation, as well as to affect de novo lipogenesis and enhance lipolysis in mature adipocytes. The same set of experiments was done in parallel on the extract obtained from fresh biomass, but no biological activity was observed. The obtainment of a high-value class of molecules in a cascade approach highlights the importance of a biorefinery approach to obtain active extracts with a concurrent lowering of the overall process costs.
MeSH
Skin, Adipogenesis, Biochemistry, Biomass, Adipocytes, Carotenoids