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Publications

Journal Article Review Epublish

PubMed: 40483532 DOI: 10.1186/s12964-025-02286-w

Neuroangiogenesis potential of mesenchymal stem cell extracellular vesicles in ischemic stroke conditions.

Cell Commun Signal 23(1):272

Authors: Behnaz Mirzaahmadi, Shahin Ahmadian, Parinaz Haddadi, Parinaz Nezhad-Mokhtari, Fereshteh Vaziri Nezamdoust, Banafsheh Yalameha, Sara Aghakhani Chegeni, Somayyeh Rashidi, Akbar Mousakhani, Emel Sokullu, Hajar Shafaei, Reza Rahbarghazi, Mohammad Karimipour

Affiliations

  • Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Department of Biochemistry, Faculty of Basic Sciences, University of Tabriz, Tabriz, Iran.
  • Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Department of Medical Biotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Research Center for Translational Medicine (KUTTAM), Koç University, Rumeli Feneri, Istanbul, Sariyer, Turkey.
  • Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Department of Anatomical Sciences, Tabriz University of Medical Sciences, Daneshghah St. Tabriz, Iran.

Abstract

Ischemic stroke (IS) is a life-threatening condition in humans with high morbidity and mortality rates in developing and industrialized countries. The occlusion of blood-supporting vessels by thrombus or emboli can contribute to massive brain cell damage, neurological deficits, and long-term disability, and in more severe conditions, results in sudden death. Current therapeutic strategies, along with rehabilitation, in part, but not completely, can restore the integrity and function of the brain. These features necessitate the advent of novel therapeutic protocols for yielding better regenerative outcomes in IS patients. In past decades, the discovery of stem cells and byproducts has led to promising results in in vitro settings and pre-clinical studies. Extracellular vesicles (EVs) are nano-sized particles released from various cell types, for instance, mesenchymal stem cells (MSCs), with certain signaling biomolecules, growth factors, and cytokines involved in cell-to-cell communication. A great plethora of studies have pointed to the fact that EVs with specific cargo can distribute easily in different parts of the body, making them appropriate therapeutics under different pathological conditions. The current review articles aimed to highlight the neuroangiogenesis properties of MSC EVs in IS conditions. How and by which mechanisms MSC EVs can orchestrate the process of nervous system regeneration is at the center of debate. We think that the current article can help us better understand MSC EVs' function in the restoration of brain function under IS conditions in terms of neurogenesis and angiogenesis.

MeSH

Cells, Extracellular Vesicles, Ischemic Stroke, Microscopy, Electron, Scanning Transmission, Stroke, Brain, Stem Cells, Mesenchymal Stem Cells, Cell Communication, Therapeutics, Angiogenesis