Journal Article Review Epublish 1 citation
PubMed: 40488318 DOI: 10.1017/erm.2025.10007
Chemically modified non-coding RNAs in cancer.
Expert Rev Mol Med 27:e19
Authors: Lulu Yang, Boyang Wang, Zhaohui Gong
Affiliations
- Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, School of Basic Medical Sciences, Health Science Center, https://ror.org/03et85d35Ningbo University, Ningbo, Zhejiang, China.
- Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, School of Basic Medical Sciences, Health Science Center, https://ror.org/03et85d35Ningbo University, Ningbo, Zhejiang, China. Department of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Abstract
BACKGROUND
Non-coding RNAs (ncRNAs) are transcribed RNA molecules that do not encode proteins but regulate diverse biological processes. Dysregulation of ncRNAs is implicated in cancer, where chemical modifications such as N6-methyladenosine (m6A), N4-acetylcytidine (ac4C), and glycosylation critically influence their function. However, these modifications, as precise regulators of ncRNA activity, have been less well-documented and understood in tumorigenesis and cancer progression.
METHODS
This article systematically analyzes the roles of chemically modified ncRNAs - ribosomal RNA (rRNA), circular RNA (circRNA) and others - in cancer biology, synthesizingevidence from published studies on their mechanistic involvement in malignancy.
RESULTS
We reveal how specific chemical modifications drive oncogenesis, impact cancer diagnosis, and affect therapeutic responses, while also exploring their prognostic potential. Furthermore, we highlight emerging connections between ncRNA epitranscriptomics and cancer.
CONCLUSIONS
This review provides novel insights into ncRNA epitranscriptomics as emerging biomarkers and intervention targets for precision oncology.
MeSH
Molecular Biology, Neoplasms, Rna, Circular, Carcinogenesis, Diagnosis, Therapeutics, Epitranscriptomics