Journal Article Review Epublish 1 citation
PubMed: 40496604 DOI: 10.2147/CCID.S524611
Advances in Genetic Polymorphism Research in Rosacea: Mechanisms and Clinical Implications.
Clin Cosmet Investig Dermatol 18:1423-1429
Authors: Zhuangyi Wang, Zhengzhong Zhang
Affiliations
- Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, People's Republic of China.
Abstract
Rosacea is a chronic inflammatory skin disease primarily affecting the central region of the face. Typical manifestations include erythema, papules, or pustules on the cheeks, glabella, chin, and nose, with some patients experiencing ocular involvement. The pathogenesis of this disease is influenced by both polygenic inheritance and environmental factors, with abnormalities in innate immunity and neurovascular regulation playing a leading role. Recent genetic studies have identified several key genes, including Human Leukocyte Antigen (HLA), Toll-Like Receptor 2 (TLR2), Interleukin-17 (IL-17), Cathelicidin Antimicrobial Peptide (CAMP), and others, that are closely associated with rosacea onset and progression. This review summarized recent advances in rosacea-related genetic researches, aiming to reveal the genetic basis of the disease and provide support for early intervention and precision management of high-risk populations.
MeSH
Genes, Genetics, Rosacea, Polymorphism, Genetic, Research, Interleukin-17