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Publications

Journal Article Epublish

PubMed: 40508196 DOI: 10.3390/ijms26115384

Circulating Aryl Hydrocarbon Receptor Is Associated with Latent Tuberculosis Infection in Patients with Type 2 Diabetes.

Int J Mol Sci 26(11)

Authors: Yu-Cheng Cheng, Wei-Chang Huang, Yu-Hsuan Li, Shin-Shin Liu, Meei-Ling Sheu, I-Te Lee

Affiliations

  • Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan. Institute of Biomedical Sciences, National Chung Hsing University, Taichung 402002, Taiwan. School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
  • Division of Pulmonary Immunology & Infectious Disease, Department of Chest Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
  • School of Medicine, Chung Shan Medical University, Taichung 402306, Taiwan.
  • Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402002, Taiwan.
  • Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
  • School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
  • Department of Computer Science & Information Engineering, National Taiwan University, Taipei 106319, Taiwan.
  • Division of Pulmonary Immunology & Infectious Disease, Department of Chest Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan. Nursing Department, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
  • Institute of Biomedical Sciences, National Chung Hsing University, Taichung 402002, Taiwan.

Abstract

Latent tuberculosis infection (LTBI) is prevalent in patients with type 2 diabetes. We aimed to examine the relationship between serum levels of aryl hydrocarbon receptor (AhR) and LTBI in patients with type 2 diabetes. In this cross-sectional study, patients with type 2 diabetes were screened for LTBI using the QuantiFERON-TB (QFT) test. Of 543 patients screened for LTBI, 133 (24.5%) were QFT-positive. The QFT-positive patients had higher AhR levels than the QFT-negative patients (44.6 [interquartile range: 25.4-58.6] pg/mL vs. 37.8 [interquartile range: 17.4-55.0] pg/mL; p = 0.004). According to the receiver operating characteristic curve, the area under the curve was 0.584 (95% confidence interval: 0.528-0.639; p = 0.004) and the optimal cutoff value for serum AhR levels was of 37.7 pg/mL for differentiating a QFT-positive result. By a multivariable logistic regression analysis, the patients with high AhR levels had a greater risk of being QFT positive than those with low AhR levels (odds ratio = 1.902, 95% confidence interval: 1.254-2.886; p = 0.003). In conclusion, in patients with type 2 diabetes, a high serum AhR level was associated with LTBI.

MeSH

Diabetes Mellitus, Receptors, Aryl Hydrocarbon, Confidence Intervals, Serum, Latent Tuberculosis, Tuberculosis, Hydrocarbons, Infections, Diabetes Mellitus, Type 2