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Publications

Journal Article Review Epublish

PubMed: 40508198 DOI: 10.3390/ijms26115390

Functional Features of Senescent Cells and Implications for Therapy.

Int J Mol Sci 26(11)

Authors: Tatiana V Kirichenko, Yuliya V Markina, Alexander M Markin, Vyacheslav S Vasilyev, Huiming Hua, Dahong Li, Anthony Yiu-Ho Woo, Roman V Deev, Ilya I Eremin, Konstantin V Kotenko

Affiliations

  • Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia.
  • Petrovsky Medical University, 119435 Moscow, Russia.
  • Medical Institute, Peoples' Friendship University of Russia Named After Patrice Lumumba (RUDN University), 117198 Moscow, Russia.
  • Institute of Plastic Surgery and Cosmetology, 105066 Moscow, Russia.
  • Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia. Petrovsky Medical University, 119435 Moscow, Russia.

Abstract

Cellular senescence is a key mechanism of aging. Senescent cells negatively affect the function of tissues and organs, significantly contributimg to the aging of the organism. Functional and structural characteristics of senescent cells, such as genomic changes and cell cycle arrest, lysosome and mitochondrial dysfunction, and production of SASP factors, are promising therapeutic targets in the context of healthy longevity. The present review was designed to characterize the features of senescent cells in order to discuss current methods and problems of geroprotective therapy and perspective factors for the development of new strategies of anti-aging treatment. Publications were searched based on the analysis of articles containing the keywords "senescent cells, aging, senolytic therapy, SASP, mitochondrial dysfunction" in the PubMed and Scopus databases up to March 2025.

MeSH

Cells, Aging, Therapeutics