Journal Article Review Epublish
PubMed: 40510422 DOI: 10.3389/fphar.2025.1586345
Targeting ferroptosis with natural products in stroke: therapeutic mechanisms and translational opportunities.
Front Pharmacol 16:1586345
Authors: Yingyi Zheng, Xi Tan, Xiaojie Wang, Rui Mao, Jianwen Guo
Affiliations
- The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
- The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
- The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Abstract
Ferroptosis is a new type of controlled cell death. It is distinguished by its reliance on iron and the production of lipid peroxidation. The role of ferroptosis in stroke has attracted a lot of attention recently. The purpose of this review is to clarify the connection between ferroptosis and stroke and to investigate the potential contribution of natural products to the clinical management of stroke and the discovery of novel medications. In this review, we summarize in detail the mechanism of ferroptosis after stroke, especially the relevant targets of ferroptosis after stroke. Furthermore, we summarize the natural products and herbal medicine currently employed in ferroptosis along with their mechanisms of action, highlighting the potential and challenges of clinical translation. We included 55 articles and classified them. After systematic screening, We think that ginkgolide B, kellerin, loureirin C, quercetin, icariside II, salvianolic acid A, berberine, Dl-3-n-butylphthalide is an effective candidate drug for the treatment of stroke.
MeSH
Cerebral Hemorrhage, Ischemic Stroke, Stroke, Ferroptosis, Therapeutics