Journal Article Review Ppublish
PubMed: 40527771 DOI: 10.1097/MD.0000000000042886
When therapy-induced senescence meets tumors: A double-edged sword: A review.
Medicine (Baltimore) 104(24):e42886
Authors: Kang Liu, Haijin Huang, Minhong Zhang, Siming Chen, Yitao Yang, Chunyun Fang, Xiaojuan Zhong
Affiliations
- Breast Surgical Department, Ganzhou Peoples Hospital, Ganzhou, Jiangxi Province, P.R. China.
- The First Affiliated Hospital Of Gannan Medical University, Ganzhou, Jiangxi Province, P.R. China.
Abstract
The tumor microenvironment (TME) significantly influences tumor development, progression, and clinical outcomes. Therapy-induced cellular senescence is a fundamental process affecting the microenvironment. This review summarizes the characteristics of therapy-induced cellular senescence, its beneficial and detrimental effects on the TME, and the underlying mechanisms contributing to its dual effects. It further elaborates on optimizing the beneficial aspects of therapy-induced cellular senescence while concomitantly mitigating its adverse effects in the treatment of tumors and prevention of recurrence. Finally, potential interventions, including antiaging drug therapies, senescence inducers, senescence clearance agents, and inhibition of adverse senescence-associated secretory phenotype (SASP) production were explored to inhibit the harmful SASP induced by therapy, with the aim of limiting the production of detrimental SASP in the TME, thereby reducing the risk of tumor recurrence.
MeSH
Neoplasms, Cellular Senescence, Therapeutics, Tumor Microenvironment