Journal Article Review Ppublish 18 citations
PubMed: 40530658 DOI: 10.1080/21645515.2025.2514357
Respiratory syncytial virus (RSV) infections in adults: Current trends and recommendations for prevention - a global challenge from a local perspective.
Hum Vaccin Immunother 21(1):2514357
Authors: Mine Durusu Tanriover, Alpay Azap, Ebru Cakir Edis, Hasan Selcuk Ozger, Husnu Pullukcu, Meliha Cagla Sonmezer, Oldac Uras Dursun, Seyhmus Merter, Abdullah Sayiner
Affiliations
- Vaccine Institute, Hacettepe Üniversitesi Aşı Enstitüsü, Ankara, Türkiye.
- Department of Infectious Diseases and Clinical Microbiology, Ankara University Faculty of Medicine, Ankara, Türkiye.
- Department of Chest Diseases, Trakya University Faculty of Medicine, Edirne, Türkiye.
- Department of Internal Medicine, Infectious Diseases, Gazi University Faculty of Medicine, Ankara, Türkiye.
- Department of Infectious Disease, Ege University Faculty of Medicine, Izmir, Türkiye.
- Department of Infectious Diseases and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.
- Pfizer Biopharmaceuticals, Istanbul, Türkiye.
- Department of Chest Diseases, Izmir University of Economics Faculty of Medicine, Izmir, Türkiye.
Abstract
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections (LRTI) and a major health threat especially for children and older adults. Epidemiological data reveal that RSV-associated global mortality rates in individuals aged ≥ 70 years exceeded those in children aged < 5 years in 2019. Although effective interventions have decreased RSV-related deaths in children aged < 5 years over time, RSV appears increasingly significant issue for the elderly and adults with underlying health conditions. Furthermore, there is currently no specific treatment for RSV infections in adults, highlighting the importance of prevention. Recently, three vaccines (RSVPreF3, RSVpreF, and mRNA-1345) have been approved for adults to date. In this article, we aimed to review the characteristics of RSV infections in adults and the evidence on the safety and efficacy of RSV vaccines, with a glimpse of the current situation in Türkiye- one of the low- and middle- income countries (LMICs).
MeSH
Respiratory Syncytial Viruses, Vaccines, Preventive Medicine, Aged, Viruses, Infections, Child, Respiratory Syncytial Virus Infections