Journal Article Systematic Review Review Ppublish
PubMed: 40545717 DOI: 10.1002/jcla.70071
The Role of Interleukin-23 and Interleukin-17 in Peri-Implant Crevicular Fluid of Subjects With Peri-Implant Disease: A Systematic Review.
J Clin Lab Anal 39(15):e70071
Authors: Mario Alberto Alarcón-Sánchez, Julieta Sarai Becerra-Ruiz, Ruth Rodríguez-Montaño, Sarah Monserrat Lomelí-Martínez, Lilibeth-Stephania Escoto-Vasquez, Artak Heboyan
Affiliations
- Molecular Biology in Medicine Program, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara, Jalisco, Mexico.
- Department of Integral Dental Clinics, Institute of Research in Dentistry, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara, Jalisco, Mexico.
- Department of Clinics, Los Altos University Center, University of Guadalajara (CUALTOS-UdeG), Tepatitlán de Morelos, Jalisco, Mexico.
- Department of Health and Illness as an Individual and Collective Process, University Center of Tlajomulco, University of Guadalajara (CUTLAJO-UdeG), Tlajomulco de Zuñiga, Jalisco, Mexico.
- Department of Medical and Life Sciences, La Ciénega University Center, University of Guadalajara (CUCIÉNEGA-UdeG), Ocotlán, Jalisco, Mexico.
- Department of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City, Mexico.
- Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
- Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia.
- Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND
Activation of the IL-23/IL-17 cytokine axis could trigger peri-implant bone loss. The aim of this review was to analyze whether in people with peri-implantitis (PI) and peri-implant mucositis (PM) the concentrations of the interleukin-23 and interleukin-17 in peri-implant crevicular fluid (PICF) are elevated compared to people with healthy dental implants (HDI).
METHODOLOGY
The protocol of this study was registered in OSF (ID: 10.17605/OSF.IO/U8NBQ) and followed PRISMA guidelines. PECO criteria were used to formulate the research question. A search strategy was performed using PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar until November 15, 2024. A rigorous evaluation was performed, and the JBI tool was used to assess the quality of the cross-sectional and case-control studies.
RESULTS
Fourteen observational studies were included in this study, with a total of 587 participants carrying 601 dental implants. The control group was represented by 252 healthy implants, while the exposure group was represented by 113 implants with PM and 236 implants with peri-implantitis. The age range of the subjects varied from 40.8 to 68.6 years, with a mean age ± standard deviation of 53.9 ± 9.9 years. The concentration of the IL-23/IL-17 cytokine axis and isoforms (IL-17E and IL-17F) was higher in subjects with peri-implant disease compared to the healthy population. Most of the studies (92.8%) showed moderate quality.
CONCLUSIONS
The concentrations of cytokines IL-23, IL-17, and IL-17E in PICF were higher in PI-affected dental implants, followed by PM-affected dental implants compared to HDI.
MeSH
Cytokines, Interleukin-23, Peri-Implantitis, Dental Implants, Biomarkers, Interleukin-17