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Publications

Journal Article Review Epublish

PubMed: 40564089 DOI: 10.3390/biomedicines13061370

Soluble CD146 in Heart Failure: Pathophysiological Role and Diagnostic Potential.

Biomedicines 13(6)

Authors: Daniela Mocan, Radu Jipa, Daniel Alexandru Jipa, Radu Ioan Lala, Maria Puschita, Florin-Claudiu Rasinar, Diana-Federica Balta, Iulia-Silvia Groza, Amelia Uzum

Affiliations

  • Multidisciplinary Doctoral School, Vasile Goldis Western University of Arad, 310025 Arad, Romania. Research Center of the Institute of Cardiovascular Diseases Timisoara, 300310 Timisoara, Romania. Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania. Institute of Cardiovascular Diseases of Timisoara, 300310 Timisoara, Romania.
  • Department of "Life Sciences", Faculty of Medicine, Vasile Goldis Western University of Arad, Romania 86, Liviu Rebreanu Street, 310048 Arad, Romania.
  • Arad County Clinical Emergency Hospital, 310037 Arad, Romania.
  • Doctoral School, Victor Babes University of Timisoara, 300041 Timisoara, Romania.
  • Victor Babes Clinical Hospital for Infectious Diseases and Pneumology of Timisoara, 300041 Timisoara, Romania.
  • Multidisciplinary Doctoral School, Vasile Goldis Western University of Arad, 310025 Arad, Romania.
  • Research Center of the Institute of Cardiovascular Diseases Timisoara, 300310 Timisoara, Romania. Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania. Institute of Cardiovascular Diseases of Timisoara, 300310 Timisoara, Romania.
  • Arad County Clinical Emergency Hospital, 310037 Arad, Romania. Doctoral School, Victor Babes University of Timisoara, 300041 Timisoara, Romania.
  • Multidisciplinary Doctoral School, Vasile Goldis Western University of Arad, 310025 Arad, Romania. Arad County Clinical Emergency Hospital, 310037 Arad, Romania.

Abstract

Heart failure (HF) remains a major global health challenge, driven by multifactorial pathophysiological processes, such as systemic congestion, endothelial dysfunction, and inflammation. While natriuretic peptides are well-established biomarkers for diagnosing and monitoring HF, they do not fully capture the complexity of vascular involvement. CD146, also known as melanoma cell adhesion molecule (MCAM), is a transmembrane glycoprotein primarily expressed on endothelial cells and involved in cell adhesion, vascular permeability, and angiogenesis. Its soluble form (sCD146), released in response to multiple pathophysiological stimuli, including venous and arterial endothelial stretch, oxidative stress, and inflammatory cytokine activation, has emerged as a promising biomarker reflecting both hemodynamic congestion and systemic endothelial stress. This review synthesizes current knowledge on the structure, regulation, and release mechanisms of CD146 and explores its clinical utility in HF. Elevated sCD146 levels have been associated with echocardiographic and radiological indicators of congestion, as well as with adverse outcomes. While promising, its application is limited by variability, lack of standardization, and confounding elevations in non-cardiac conditions, including malignancy.

MeSH

Cells, Tissue Adhesions, Heart Failure, Heart, Stress, Physiological, Biomarkers, Cell Adhesion