Journal Article Review Epublish
PubMed: 40565811 DOI: 10.3390/jcm14124065
Uterine Fibroids and Their Association with Acute and Chronic Venous Thromboembolic Disease-An Expert Review of the Literature.
J Clin Med 14(12)
Authors: Munaza Afaq, Brooke Alexa Zlotshewer, Estefania Oliveros, Sarah Gabrielle Bauman, Anjali Vaidya, Vladimir Lakhter, Paul Forfia, Ahmed S Sadek, Enrique Hernandez, Riyaz Bashir
Affiliations
- Department of Cardiovascular Diseases, Temple University Hospital, Philadelphia, PA 19140, USA.
- Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA.
- Charles E. Krausz Library, Temple University School of Podiatry Medicine-TUSPM, Philadelphia, PA 19107, USA.
- Department of Obstetrics and Gynecology, Temple University Hospital, Philadelphia, PA 19140, USA.
Abstract
Venous thromboembolism is significantly affected by hormonal and reproductive factors that pose unique challenges in women. Among various risk factors, the role of uterine fibroids, which are the most common benign tumors in women, is not well understood. The relationship between venous thromboembolism and fibroids is mainly attributed to the physical compression caused by large fibroids on pelvic veins, particularly the iliac veins, leading to venous stasis and thrombosis. This review explores the prevalence, pathogenesis, risk factors, possible racial influences, and management strategies of venous thromboembolism associated with fibroids. It highlights the need for better awareness, considering the asymptomatic nature of many fibroids and their potential to lead to serious thromboembolic complications. There is a clear need for screening methods, detailed guidelines, and treatments to prevent such complications and improve women's health care.
MeSH
Thromboembolism, Risk Factors, Leiomyoma, Venous Thromboembolism, Veins