Journal Article Review Epublish 9 citations
PubMed: 40573384 DOI: 10.3390/v17060793
Insights into the Currently Available Drugs and Investigational Compounds Against RSV with a Focus on Their Drug-Resistance Profiles.
Viruses 17(6)
Authors: Alessia Magnapera, Anna Riccio, Antonio Curcio, Caterina Tramontozzi, Lorenzo Piermatteo, Stefano D'Anna, Stefano Alcaro, Claudia Alteri, Simone La Frazia, Anna Artese, Romina Salpini, Valentina Svicher
Affiliations
- Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
- Department of Health Science, Magna Graecia University, 88100 Catanzaro, Italy.
- Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.
- Microbiology and Virology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Abstract
Respiratory syncytial virus (RSV) is a leading cause of severe respiratory illness in infants, young children, as well as elderly and immunocompromised patients worldwide. RSV is classified into two major subtypes, RSV-A and RSV-B, and remains the most frequently detected pathogen in infants hospitalized with acute respiratory infections. Recent advances have brought both passive and active immunization strategies, including FDA-approved vaccines for older adults and pregnant women and new monoclonal antibodies (mAbs) for infant protection. Although significant progress has been made, the need remains for improved antiviral treatments, particularly for vulnerable infants and immunocompromised patients. Recent studies have identified multiple RSV mutations that confer resistance to current treatments. These mutations, detected in both in vitro studies and clinical isolates, often complicate therapeutic outcomes, underscoring the need for updated and effective management strategies. In this context, evaluating protein flexibility through tools like DisoMine provides insight into how specific mutations impact structural dynamics at binding sites, thus affecting ligand affinity. This review aims to synthesize these aspects, offering a comprehensive insight into ongoing efforts to counteract RSV and address the evolving challenge of drug resistance.
MeSH
Respiratory Syncytial Viruses, Pharmaceutical Preparations, Virology, Immunocompromised Host, Therapeutics, Mutation, Infant, Drug Resistance