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Journal Article Ppublish 2 citations

PubMed: 40576006 DOI: 10.5468/ogs.25052

Role of random blood glucose and HbA1c levels in optimizing glucose tolerance screening in early pregnancy: a retrospective cohort study.

Obstet Gynecol Sci 68(4):273-282

Authors: Yoshitsugu Chigusa, Yoshikazu Ikeda, Akitoshi Yamamura, Haruta Mogami, Akiko Nishimura, Satoshi Morita, Masaki Mandai, Shin-Ichi Harashima

Affiliations

  • Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Department of Obstetrics and Gynecology, Yasaka Hospital, Kyotango, Japan.
  • Department of Chronic Care Nursing, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Department of Internal Medicine and Diabetes, Goshominami Harashima Clinic, Kyoto, Japan.
  • Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Research Department, Health Care Research Center, Nagahama Municipal Hospital, Shiga, Japan.
  • Department of Clinical Research Planning and Administration, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Abstract

OBJECTIVE

Random blood glucose (rBG) levels are commonly measured in Japan; however, no standardized cutoff values exist for glucose tolerance screening in early pregnancy. The contribution of glycated hemoglobin (HbA1c) and glycated albumin (GA) measurements to the diagnosis of gestational diabetes mellitus (GDM) remains unclear. Therefore, we aimed to evaluate the significance of these glycemic indicators in early pregnancy for predicting GDM.

METHODS

This observational cohort study enrolled pregnant women who underwent initial prenatal examinations to determine their rBG, HbA1c, and GA levels at a rural maternity facility. Clinical data were retrospectively reviewed.

RESULTS

A total of 449 patients were analyzed, comprising 394 with normal glucose tolerance (NGT) and 55 with GDM. The rBG, HbA1c, and GA levels were significantly higher during early pregnancy in women who developed GDM than in those with NGT. Receiver operating characteristic curve analysis revealed that the areas under the curve (AUC) for rBG, HbA1c, and GA were 0.733, 0.591, and 0.608, respectively, with cutoff values of 100 mg/dL, 5.2%, and 14.6%, respectively. These cutoff values had sensitivities of 52.7%, 70.9%, and 36.4% and specificities of 87.6%, 43.4%, and 82.5%, respectively. The product of rBG and HbA1c levels demonstrated improved performance, with an AUC of 0.750, cutoff value of 509, 63.6% sensitivity, and 83.5% specificity.

CONCLUSION

Glucose tolerance screening in early pregnancy using an rBG level of 100 mg/dL and an HbA1c level of 5.2% as cutoff values may help identify high-risk cases and enable early diagnosis of GDM.

MeSH

Diabetes Mellitus, Diabetes, Gestational, Pregnancy, Blood Glucose, Blood, Cohort Studies, Diagnosis