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Journal Article Ppublish 11 citations

PubMed: 40579052 DOI: 10.1016/j.jacadv.2025.101788

Lifestyle Interventions in Cardiovascular-Kidney-Metabolic Syndrome JACC: Advances Expert Panel.

JACC Adv 4(6 Pt 2):101788

Authors: Izza Shahid, Jerrin Philip, Eleonora Avenatti, Deepika Laddu, Michael D Shapiro, Amit Khera, Ambarish Pandey, Chiadi E Ndumele, Martha Gulati, Khurram Nasir, Kershaw V Patel

Affiliations

  • Division of Preventive Cardiology, Houston Methodist Academic Institute, Houston, Texas, USA.
  • Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA.
  • Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA.
  • Center for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA.

Abstract

Cardiovascular-kidney-metabolic (CKM) syndrome impacts nearly all organ systems, with progressive dysfunction leading to morbidity and mortality. The high burden of CKM syndrome requires accessible, scalable, and low-cost interventions to prevent downstream complications. Nonpharmacologic interventions targeting lifestyle factors, such as diet, physical activity, and behavioral modification, represent the cornerstone of CKM syndrome management to prevent a progressive disease and associated adverse outcomes. Lifestyle interventions play a key role not only in primordial and primary prevention in the earlier stages of CKM syndrome (stages 0-2) but also in subclinical cardiovascular disease (stage 3) as well as prevalent cardiovascular disease (stage 4). The purpose of the present review is to describe the evidence from randomized clinical trials for specific lifestyle interventions across CKM syndrome stages. This review will explore the impact of lifestyle interventions in each CKM syndrome stage and how they impact interrelated systems.

MeSH

Exercise, Life Style, Cardiovascular Diseases, Kidney, Diet, Metabolic Syndrome

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