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Publications

Journal Article Review Ppublish

PubMed: 40580483 DOI: 10.1080/19490976.2025.2526716

Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment.

Gut Microbes 17(1):2526716

Authors: Taoxing Peng, Yiqi Wan, Yuxuan Sun, Yuexiang Ren, Fuli Shi, Yangfeng Lv, Xiangqiong Wen, Qiongfeng Chen, Xianhe Yang, Shan Xu, Jianming Li

Affiliations

  • The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Postdoctoral Research Station, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Postdoctoral Research Station, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Department of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • School of Basic Medical Sciences, Nanchang University, Nanchang, China.
  • Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. School of Basic Medical Sciences, Nanchang University, Nanchang, China.
  • The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. Department of Pathology, Soochow University Medical School, Suzhou, China.

Abstract

Circadian rhythms govern physiological activities through the precise modulation of gene expression and biochemical functions. Dysfunction of circadian rhythms is associated with an increased risk of tumor formation, growth, and metastasis, as well as alterations in the gut microbiota (GM) and the tumor microenvironment (TME). Indeed, the intricate regulatory interactions between the circadian system, GM, and TME present a promising area for further exploration. This review, centered on the circadian system, focuses on the dynamics in the GM and the TME driven by circadian dysfunction. Additionally, it places particular emphasis on the interplay between circadian rhythms and GM. The review further explores how this interplay can be therapeutically leveraged to normalize the TME and enhance clinical outcomes. For the first time, the rhythms-microbiota-microenvironment axis is proposed, linking the circadian system, GM, and TME. Circadian dysfunction significantly impacts this axis, leading to disruptions in both the GM and TME. The review also provides the latest insights and innovative therapies from the perspective of the interplay between circadian rhythms and GM.

MeSH

Circadian Rhythm, Neoplasms, Gastrointestinal Microbiome, Tumor Microenvironment, Microbiota