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Publications

Journal Article Review Ppublish

PubMed: 40588525 DOI: 10.1038/s12276-025-01481-6

Progressing future osteoarthritis treatment toward precision medicine: integrating regenerative medicine, gene therapy and circadian biology.

Exp Mol Med 57(6):1133-1142

Authors: Ee Hyun Kim, Seungho Jeon, Junyoung Park, Ji Hyun Ryu, Ali Mobasheri, Csaba Matta, Eun-Jung Jin

Affiliations

  • Integrated Omics Institute, Wonkwang University, Iksan, Republic of Korea.
  • Department of Biomedical Materials Science, Graduate School of JABA, Wonkwang University, Iksan, Republic of Korea.
  • Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
  • Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
  • Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Université de Liège, Liège, Belgium.
  • Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Integrated Omics Institute, Wonkwang University, Iksan, Republic of Korea. Department of Biomedical Materials Science, Graduate School of JABA, Wonkwang University, Iksan, Republic of Korea.

Abstract

Osteoarthritis (OA) is marked by cartilage degradation, inflammation and varied pain. Traditional treatments such as nonsteroidal anti-inflammatory drugs primarily offer symptom relief without halting disease progression. Advances in regenerative medicine and stem cell and gene therapies, combined with innovative biomaterials such as hydrogels, present new opportunities to target the underlying pathophysiology of OA. This review explores these promising approaches alongside the emerging roles of circadian biology and organelle health in OA pathogenesis and therapy. It highlights the shift toward precision medicine, offering a comprehensive analysis of emerging targeted strategies aimed at improving OA management and patient outcomes.

MeSH

Genes, Regenerative Medicine, Osteoarthritis, Precision Medicine, Therapeutics