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Publications

Journal Article Scoping Review Epublish

PubMed: 40589858 DOI: 10.7717/peerj.19575

Structural and functional neuroimaging of hippocampus to study adult neurogenesis in long COVID-19 patients with neuropsychiatric symptoms: a scoping review.

PeerJ 13:e19575

Authors: Jayakumar Saikarthik, Ilango Saraswathi, Bijaya Kumar Padhi, Muhammad Aaqib Shamim, Nasser Alzerwi, Abdulaziz Alarifi, Aravind P Gandhi

Affiliations

  • Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Majmaah University, Al Majmaah, Saudi Arabia.
  • SIMATS University, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.
  • Department of Medical Education, University of Dundee, Dundee, United Kingdom.
  • Department of Physiology, Madha Medical College and Research Institute, Chennai, India. Department of Business Administration, Manipal Academy of Higher Education, Manipal, India.
  • Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, India.
  • Department of Surgery, College of Medicine, Majmaah University, Al Majmaah, Saudi Arabia.
  • Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
  • King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
  • Department of Community Medicine, All India Institute of Medical Sciences, Nagpur, India.

Abstract

Background

Worsening of neuropsychiatric and neurodegenerative disorders occurs in COVID-19. Impaired adult neurogenesis is linked to most of the neuropsychiatric symptoms and disorders.

Aim

The current scoping review identified and mapped the available evidence on adult neurogenesis in long COVID-19, at a global level following the JBI methodology for scoping reviews and followed the framework by Arksey and O'Malley.

Method

Original studies focusing on structural and functional neuroimaging of the hippocampus to study adult neurogenesis in long COVID-19 were included in the review. Studies published in English language with no restriction on the time of publication were searched using the specified search strategy in PubMed, Web of Science, Embase, and SCOPUS. Articles obtained from the database search were collated and uploaded into the Nested Knowledge AutoLit semi-automated systematic review platform for data extraction.

Results

The current review provides evidence of the potential alterations in adult neurogenesis in long COVID-19 and its potential link to neuropsychiatric sequelae of long COVID-19, with further research required to validate this assertion.

Conclusion

This review proposes conceptual and methodological approaches for future investigations to address existing limitations and elucidate the precise role of adult neurogenesis in the pathophysiology and treatment of long COVID-19.

MeSH

Hippocampus, Neurogenesis, Functional Neuroimaging, Neuroimaging, Signs And Symptoms, Covid-19, Post-Acute Covid-19 Syndrome