Journal Article Review Epublish
PubMed: 40592821 DOI: 10.1038/s41419-025-07784-w
Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations.
Cell Death Dis 16(1):467
Authors: Anton Tkachenko, Mohammad A Alfhili, Jawaher Alsughayyir, Alessandro Attanzio, Abdulla Al Mamun Bhuyan, Bożena Bukowska, Antonio Cilla, Martha A Quintanar-Escorza, Michael Föller, Ondrej Havranek, Kashif Jilani, Anatolii Onishchenko, Etheresia Pretorius, Volodymyr Prokopiuk, Ignazio Restivo, Luisa Tesoriere, Grazia Maria Virzì, Thomas Wieder
Affiliations
- Department of Cryobiochemistry, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine.
- BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.
- Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
- Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
- Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy.
- Department of Veterinary and Animal Sciences, University of Rajshahi-6205, Rajshahi, Bangladesh.
- Department of Biophysics of Environmental Pollution, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
- Nutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, Burjassot, Spain.
- Medicine and Nutrition Faculty, Universidad Juárez del Estado de Durango, Durango, Dgo, México.
- Department of Physiology, University of Hohenheim, Stuttgart, Germany.
- BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.
- First Department of Internal Medicine-Hematology, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.
- Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan.
- Department of Cryobiochemistry, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine.
- Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.
- Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
- Research Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv, Ukraine.
- Department of Nephrology, Dialysis and Transplant, St Bortolo Hospital, Vicenza, Italy.
- IRRIV - International Renal Research Institute Vicenza, Vicenza, Italy.
- Institute of Physiology I, Eberhard Karls University Tübingen, Tübingen, Germany.
Abstract
Early studies have shown that erythrocytes have caspase-3 and caspase-8 and are capable of dying through an apoptotic-like cell death triggered by Ca 2+ ionophores. This cell death is associated with apoptosis-like morphological signs, including cell shrinkage, membrane blebbing, and phosphatidylserine externalization. To emphasize that mature erythrocytes don't have the apoptotic mitochondrial machinery and distinguish this unique cell death modality from apoptosis, it was named "eryptosis". Over recent decades, our knowledge of eryptosis has been significantly expanded, providing more insights into the uniqueness of cell death pathways in erythrocytes. In this review, we aim to summarize our current understanding of eryptosis, formulate the nomenclature and guidelines to interpret results of eryptosis studies, provide a synopsis of morphological and biochemical features of eryptosis, and highlight the role of eryptosis in health and disease, including its druggability.
MeSH
Cells, Erythrocytes, Caspases, Eryptosis, Apoptosis, Cell Death