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Publications

Journal Article Review Epublish

PubMed: 40593725 DOI: 10.1038/s41467-025-61239-6

Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation.

Nat Commun 16(1):5709

Authors: Gokhan Burcin Kubat, Pasquale Picone, Erkan Tuncay, Leila Aryan, Antonella Girgenti, Laura Palumbo, Ibrahim Turkel, Firat Akat, Keshav K Singh, Domenico Nuzzo

Affiliations

  • Institute of Transplantation and Gene Sciences, Baskent University, Ankara, Türkiye.
  • Department of Exercise and Sport Sciences, Faculty of Health Sciences, Baskent University, Ankara, Türkiye.
  • Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedica, Palermo, Italy.
  • Department of Biophysics, Faculty of Medicine, Ankara University, Ankara, Türkiye.
  • Department of Interdisciplinary Neuroscience, Ankara University, Ankara, Türkiye.
  • Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedica, Palermo, Italy.
  • Department of Exercise and Sport Sciences, Faculty of Sport Sciences, Hacettepe University, Ankara, Türkiye.
  • Department of Physiology, Faculty of Medicine, Ankara University, Ankara, Türkiye.
  • Departments of Genetics, Dermatology and Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Abstract

Mitochondrial dysfunction contributes to aging and diseases like neurodegeneration and cardiovascular disorders. Mitochondria transfer and transplantation (MTT) represent promising therapeutic strategies aimed at restoring cellular function by introducing functional mitochondria into damaged cells. However, challenges like transfer efficiency, stability, and cellular integration limit clinical application. Recent biotechnological advances-such as liposomes, extracellular vesicles, and surface modifications-enhance mitochondrial protection, targeting, and biocompatibility. This Perspective highlights recent progress in MTT, its therapeutic potential, and current limitations. We also discuss the need for scalable, clinically translatable approaches and appropriate regulatory frameworks to realize the full potential of mitochondria-based nanotherapies in modern medicine.

MeSH

Mitochondria, Therapeutics, Transplantation

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